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RUB » Faculty of Medicine » Biochemistry and Pathobiochemistry » Systems Biochemistry

Publications

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2024

• Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif
  Stefan Gaussmann, Rebecca Peschel, Julia Ott, Krzysztof M Zak, Judit Sastre, Florent Delhommel, Grzegorz M Popowicz, Job Boekhoven, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler
  Nat Commun . 2024 Apr 18;15(1):3317. doi: 10.1038/s41467-024-47605-w.
• ATP-Dependent Steps in Peroxisomal Protein Import
  Harald W Platta, Julia Jeske, Nadine Schmidt, Ralf Erdmann
  Annu Rev Biochem . 2024 Apr 15. doi: 10.1146/annurev-biochem-030222-111227.

2023

• PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival
  Lavanya Mahadevan, Hemant Arya, Andrea Droste, Wolfgang Schliebs, Ralf Erdmann, Vishal C Kalel
  Front Cell Infect Microbiol. 2024 Mar 6:14:1274506. doi: 10.3389/fcimb.2024.1274506. eCollection 2024.
• Physiological constraints limiting the growth of Drosophila larvae
  Jürgen Schönborn, Irfan Akhtar, Andrea Droste, Stephanie Wesemann, Mathias Beller
  preprint doi: https://doi.org/10.1101/2023.12.20.572459
• HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
  Viktoria Stab, Christiane Stahl-Hennig, Armin Ensser, Elie Richel, Kirsten Fraedrich, Ulrike Sauermann, Bettina Tippler, Florian Klein, Dennis R Burton, Matthias Tenbusch, Klaus Überla
  Cell Rep Med . 2023 Sep 30:101201. doi: 10.1016/j.xcrm.2023.101201. Online ahead of print.
• Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
  Maximilian Rüttermann, Michelle Koci, Pascal Lill , Ermis Dionysios Geladas, Farnusch Kaschani, Björn Udo Klink, Ralf Erdmann, Christos Gatsogiannis
  Nat Commun . 2023 Sep 23 ;14(1):5942. doi: 10.1038/s41467-023-41640-9.
• Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes
  Chethan K Krishna, Nadine Schmidt, Bettina G Tippler, Wolfgang Schliebs, Martin Jung, Konstanze F Winklhofer, Ralf Erdmann, Vishal C Kalel
  Front Cell Dev Biol. 11:1213761. doi: 10.3389/fcell.2023.1213761. eCollection 2023. Front Cell Dev Biol.
• Import and quality control of peroxisomal proteins.
  Markus Rudowitz, Ralf Erdmann
  J Cell Sci. 2023 Aug 1;136(15):jcs260999. doi: 10.1242/jcs.260999. Epub 2023 Aug 8.
• Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template.
  Monika Marciniak , Piotr Mróz, Valeria Napolitano, Vishal C Kalel, Roberto Fino, Emilia Pykacz, Wolfgang Schliebs, Oliver Plettenburg, Ralf Erdmann, Michael Sattler, Grzegorz M Popowicz, Maciej Dawidowski
  Eur J Med Chem. 2023 Oct 5;258:115587. doi: 10.1016/j.ejmech.2023.115587. Epub 2023 Jun 25.
• Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1
  Renate L M Jansen, Marco van den Noort, Arjen M Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J van der Klei
  Biochim Biophys Acta Mol Cell Res, 2023 Apr 5;1870(5):119471. doi: 10.1016/j.bbamcr.2023. 119471. Online ahead of print.
• Biochemical Fractionation of Trypanosomes for the Analysis of Glycosomal Protein Import Defects
  Shih-En Chou, Vishal C Kalel, Ralf Erdmann
  Methods Mol Biol. 2643:445-453. doi: 10.1007/978-1-0716-3048-8_32, 2023
• Affinity Purification of Soluble and Membrane-Bound Protein Complexes by a FlpIn Strategy
  Rebecca Peschel, Nadine Schmidt, Wolfgang Schliebs, Ralf Erdmann
  Methods Mol Biol. 2643:373-382. doi: 10.1007/978-1-0716-3048-8_26, Methods Mol Biol.
• Isolation of Glycosomes from Trypanosoma brucei
  Chethan K Krishna, Laura Franke, Ralf Erdmann, Vishal C Kalel
  Methods Mol Biol. 2643:33-45. doi: 10.1007/978-1-0716-3048-8_3., 2023
• Utilization of Nonstop mRNA to Assess Ribosome-Associated Nascent Polypeptide Chains in Early Topogenesis of Peroxisomal Proteins
  Markus Rudowitz, Luis Daniel Cruz-Zaragoza, Wolfgang Girzalsky, Ralf Erdmann
  Methods Mol Biol. 2643:383-390. doi: 10.1007/978-1-0716-3048-8_27, 2023
• Highlight: structure and function of the peroxisomal translocon
  Ralf Erdmann
  Biol Chem, 2023 Jan 5. doi: 10.1515/hsz-2022-0344. Online ahead of print.

2022

• Editorial: Structural aspects of peroxisome biogenesis and functions
  Marek Skoneczny, Tânia Francisco, Ralf Erdmann, Christos Gatsogiannis
  Front Cell Dev Biol . 2022 Dec 15;10:1114759. doi: 10.3389/fcell.2022.1114759. doi: 10.3389/fcell.2022.1114759.
• Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis
  Julia Ott, Jessica Sehr, Nadine Schmidt, Wolfgang Schliebs, Ralf Erdmann
  Biol Chem, 2022 Dec 19. doi: 10.1515/hsz-2022-0223. Online ahead of print.
• Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14
  Mohanraj Gopalswamy, Chen Zheng, Stefan Gaussmann, Hamed Kooshapur, Eva Hambruch, Wolfgang Schliebs, Ralf Erdmann, Iris Antes, Michael Sattler
  Biol Chem. 2022 Nov 28. doi: 10.1515/hsz-2022-0177. Online ahead of print
• Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5
  S Galiani, K Reglinski, P Carravilla, A Barbotin, I Urbančič, J Ott, J Sehr, E Sezgin , F Schneider, D Waithe, P Hublitz, W Schliebs, R Erdmann, C Eggeling
  Biophys Rep (N Y) . 2022 Jun 8;2(2):None. doi: 10.1016/j.bpr.2022.100055
• Determining the targeting specificity of the selective peroxisomal targeting factor Pex9
  Eden Yifrach, Markus Rudowitz, Luis Daniel Cruz-Zaragoza, Asa Tirosh, Zohar Gazi, Yoav Peleg, Markus Kunze 4 , Miriam Eisenstein 1 , Wolfgang Schliebs 2 , Maya Schuldiner 1 , Ralf Erdmann 2 , Einat Zalckvar
  Biol Chem. 2022 Oct 24. doi: 10.1515/hsz-2022-0116. Online ahead of print.
• Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer
  Daniel Blum, Maren Reuter, Wolfgang Schliebs, Jana Tomaschewski, Ralf Erdmann, Richard Wagner
  Biol Chem, 2022 Oct 20. doi: 10.1515/hsz-2022-0183. Online ahead of print.
• Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma
  Valeria Napolitano, Piotr Mróz, Monika Marciniak, Vishal C Kalel, Charlotte A Softley, Julian D Janna Olmos, Bettina G Tippler, Kenji Schorpp, Sarah Rioton, Tony Fröhlich, Oliver Plettenburg, Kamyar Hadian, Ralf Erdmann, Michael Sattler, Grzegorz M Popowicz, Maciej Dawidowski, Grzegorz Dubin
  Eur J Med Chem. 2022 Sep 27;243:114778. doi: 10.1016/ j.ejmech.2022.114778. Online ahead of print.
• Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions
  Eden Yifrach, Duncan Holbrook-Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo Wt van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz , Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar
  Mol Syst Biol . 2022 Sep;18(9):e11186. doi: 10.15252/msb.202211186
• Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes
  Sven Fischer, Jérôme Bürgi, Shiran Gabay-Maskit, Renate Maier, Thomas Mastalski, Eden Yifrach, Agnieszka Obarska-Kosinska, Markus Rudowitz, Ralf Erdmann, Harald W Platta, Matthias Wilmanns, Maya Schuldiner, Einat Zalckvar, Silke Oeljeklaus, Friedel Drepper, Bettina Warscheid
  Biol Chem. 2022 Sep 21. doi: 10.1515/hsz-2022-0168.
• Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma
  Valeria Napolitano, Charlotte A Softley, Artur Blat, Vishal C Kalel, Kenji Schorpp, Till Siebenmorgen , Kamyar Hadian, Ralf Erdmann, Michael Sattler, Grzegorz M Popowicz, Grzegorz Dubin
  Sci Rep. 2022 Aug 29; 12(1):14705. doi: 10.1038/s41598-022-18841-1.
• Dynamics of the translocation pore of the human peroxisomal protein import machinery
  Mausumi Ghosh, Niels Denkert, Maren Reuter, Jessica Klümper, Katharina Reglinski, Rebecca Peschel, Wolfgang Schliebs, Ralf Erdmann, Michael Meinecke
  Biol Chem 2022 Aug 18. doi: 10.1515/hsz-2022-0170. Online ahead of print
• The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy
  Harald W Platta, Ralf Erdmann
  J Cell Biol. 2022 Jan 3; 221(1):e202111008. doi: 10.1083/jcb.202111008
• Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction
  Mengqiao Li, Stefan Gaussmann, Bettina Tippler , Julia Ott, Grzegorz M Popowicz, Wolfgang Schliebs, Michael Sattler, Ralf Erdmann, Vishal C Kalel
  Front Cell Dev Biol, 2021 Dec 20;9:737159. doi: 10.3389/fcell.2021.737159. eCollection 2021

2021

• Edgetic Perturbations Contribute to Phenotypic Variability in PEX26 Deficiency
  Amelie S Lotz-Havla, Mathias Woidy, Philipp Guder, Jessica Schmiesing, Ralf Erdmann, Hans R Waterham, Ania C Muntau, Søren W Gersting
  Front Genet 2021 Nov 4;12:726174. doi: 10.3389/fgene.2021.726174. eCollection 2021
• COVID-19, Neuropathology, and Aging: SARS-CoV-2 Neurological Infection, Mechanism, and Associated Complications
  Rajkumar Singh Kalra, Jaspreet Kaur Dhanjal, Avtar Singh Meena, Vishal C Kalel, Surya Dahiya, Birbal Singh, Saikat Dewanjee , Ramesh Kandimalla
  Front Aging Neurosci 2021 Jun 3;13:662786. doi: 10.3389/fnagi.2021.662786. eCollection 2021.
• Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents
  Roberto Fino, Dominik Lenhart, Vishal C Kalel, Charlotte A Softley , Valeria Napolitano, Ryan Byrne, Wolfgang Schliebs, Maciej Dawidowski, Ralf Erdmann, Michael Sattler, Gisbert Schneider, Oliver Plettenburg, Grzegorz M Popowicz
  J Chem Inf Model . 2021 Oct 25;61(10):5256-5268. doi: 10.1021/acs.jcim.1c00472. Epub 2021 Oct 1
• Challenges of using Expansion Microscopy for super-resolved imaging of cellular organelles
  Maximilian Büttner, Christoffer B Lagerholm, Dominic Waithe, Silvia Galiani, Wolfgang Schliebs, Ralf Erdmann, Christian Eggeling, Katharina Reglinski
  Chembiochem. 2021 Feb 15;22(4):686-693. doi: 10.1002/cbic.202000571. Epub 2020 Nov 11.
• iBRET Screen of the ABCD1 Peroxisomal Network and Mutation- Induced Network Perturbations
  Amelie S. Lotz-Havla,* Mathias Woidy, Philipp Guder, Caroline C. Friedel, Julian M. Klingbeil, Ana-Maria Bulau, Anja Schultze, Ilona Dahmen, Heidi Noll-Puchta, Stephan Kemp, Ralf Erdmann, Ralf Zimmer, Ania C. Muntau, and Søren W. Gersting*
  Journal of proteome research doi.org/10.1021/acs.jproteome.1c00330 2021
• The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity
  Bastian Grewe 1, Carolin Vogt 2, Theresa Horstkötter 2, Bettina Tippler 1,3, Han Xiao 1,4, Bianca Müller 1, Klaus Überla 1,4 , Ralf Wagner 5,6, Benedikt Asbach and Jens Bohne 2,*
  Viruses 2021, 13(6), 997; https://doi.org/10.3390/v13060997 2021
• Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14
  Stefan Gaussmann 1 2 , Mohanraj Gopalswamy 1 2 , Maike Eberhardt 1 2 , Maren Reuter 3 , Peijian Zou 1 2 , Wolfgang Schliebs 3 , Ralf Erdmann 3 , Michael Sattler 1 2
  Front Cell Dev Biol. 2021 Apr 16 ;9:651449. doi: 10.3389/fcell.2021.651449. eCollection 2021.
• Current advances in the function and biogenesis of peroxisomes and their roles in health and disease
  Noa Dahan 1 , Tania Francisco 2 , Christian Falter 3 , Tony Rodrigues 2 , Vishal Kalel 4 , Markus Kunze 5 , Tobias Hansen 4 , Wolfgang Schliebs 4 , Ralf Erdmann 6
  Histochem Cell Biol. 2021 Apr 5. doi: 10.1007/s00418-021-01982-1. Online ahead of print. 2021
• Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility
  Maren Reuter, Hamed Kooshapur, Jeff-Gordian Suda, Stefan Gaussmann, Alexander Neuhaus, Lena Brühl, Pratima Bharti, Martin Jung, Wolfgang Schliebs, Michael Sattler, Ralf Erdmann
  J Mol Biol. 166765. doi: 10.1016/j.jmb.2020.166765. Online ahead of print. 2021 Jan 20

2020

• Towards the molecular architecture of the peroxisomal receptor docking complex
  Pascal Lill, Tobias Hansen, Daniel Wendscheck, Bjoern Udo Klink, Tomasz Jeziorek, Dimitrios Vismpas, Jonas Miehling, Julian Bender, Andreas Schummer, Friedel Drepper, Wolfgang Girzalsky, Bettina Warscheid, Ralf Erdmann, Christos Gatsogiannis
  PNAS first published December 15 2020
• A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast
  Shiran Gabay-Maskit 1 , Luis Daniel Cruz-Zaragoza 2 , Nadav Shai 1 , Miriam Eisenstein 1 , Chen Bibi 1 , Nir Cohen 1 , Tobias Hansen 2 , Eden Yifrach 1 , Nofar Harpaz 1 , Ruth Belostotsky 3 , Wolfgang Schliebs 2 , Maya Schuldiner 4 , Ralf Erdmann 5 , Einat Zalckvar 4
  J Cell Sci jcs.244376. doi: 10.1242/jcs.244376. Online ahead of print. 2020 Nov 11
• Fluidity and lipid composition of membranes of peroxisomes, mitochondria and the ER from oleic acid-induced Saccharomyces cerevisiae
  Katharina Reglinski1, Laura L. Steinfort2, Erdinc Sezgin3, Christian Klose4, Harald W. Platta2, Wolfgang Girzalsky2, Christian Eggeling1 and Ralf Erdmann2*
  Front. Cell Dev. Biol. doi: 10.3389/fcell.2020.574363 2020
• Membrane processing and steady-state regulation of the alternative peroxisomal import receptor Pex9p
  Markus Rudowitz1, Ralf Erdmann1* and Wolfgang Schliebs1*
  Front. Cell Dev. Biol. | doi: 10.3389/fcell.2020.566321 2020
• Pex14p phosphorylation modulates import of citrate synthase 2 into peroxisomes in Saccharomyces cerevisiae
  Andreas Schummer, Renate Maier, Shiran Gabay-Maskit, Tobias Hansen, Wignand W. D. Mühlhäuser, Ida Suppanz, Amir Fadel, Maya Schuldiner, Wolfgang Girzalsky, Silke Oeljeklaus, Einat Zalckvar, Ralf Erdmann, View ORCID ProfileBettina Warscheid
  Front. Cell Dev. Biol. doi: https://doi.org/10.1101/2020.07.03.186833, in press
• The Peroxisomal Targeting Signal 3 (PTS3) of the Budding Yeast Acyl-CoA Oxidase is a Signal Patch
  Błażej Kempiński, Anna Chełstowska, Jarosław Poznański, Kamil Król, Łukasz Rymer, Zuzanna Frydzińska, Wolfgang Girzalsky, Adrianna Skoneczna, Ralf Erdmann and Marek Skoneczny
  Front. Cell Dev. Biol. doi: 10.3389/fcell.2020.00198. eCollection 2020 2020 Mar 27;8:198
• The novel peroxin Pex37: the Pxmp2-family joins the peroxisomal fission machinery.
  Platta. H.W. & Erdmann R.
  FEBS J. 287(9), 1737-1741 (2020) (2020)
• Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
  Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM.
  J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6.

2019

• Evolutionary divergent PEX3 is essential for glycosome biogenesis and survival of trypanosomatid parasites.
  Kalel VC, Li M, Gaussmann S, Delhommel F, Schäfer AB, Tippler B, Jung M, Maier R, Oeljeklaus S, Schliebs W, Warscheid B, Sattler M, Erdmann R.
  Biochim Biophys Acta Mol Cell Res. 2019 Jul 29;1866(12):118520. doi: 10.1016/j.bbamcr.2019.07.015. [Epub ahead of print]
• Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.
  Schrul B, Schliebs W.
  Biol Chem. 399(7):741-749. 2018 Jun 27; doi: 10.1515/hsz-2018-0125. Review. PMID: 29500918
• Current advances in protein import into Peroxisomes
  Walter T, Erdmann R
  The Protein Journal [Epub ahead of print]
• The deubiquitination of the PTS1-import receptor Pex5p is required for peroxisomal matrix protein import
  El Magraoui F, Brinkmeier R, Mastalski T, Hupperich A, Strehl C, Schwerter D, Girzalsky W, Meyer HE, Warscheid B, Erdmann R, Platta HW
  Biochim Biophys Acta Mol Cell Res 1866 (2), , 199-213 (2019)

2018

• Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development
  Kalel VC, Mäser P, Sattler M, Erdmann R, Popowicz GM
  Curr Opin Microbiol 46 , 116-213 (2018)
• Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p.
  Schwerter D1, Grimm I1, Girzalsky W1, Erdmann R2
  J Biol Chem 293 , 15458-470 (2018)
• Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.
  Mbekeani AJ1, Stanley WA2, Kalel VC3, Dahan N4, Zalckvar E5, Sheiner L6, Schliebs W7, Erdmann R8, Pohl E9, Denny PW10.
  Genes (Basel). 2018 Aug 29;9(9). pii: E434. doi: 10.3390/genes9090434.
• Using Pull Down Strategies to Analyze the Interactome of Peroxisomal Membrane Proteins in Human Cells.
  Klümper J1, Oeljeklaus S2, Warscheid B2, Erdmann R1, Schliebs W3.
  Subcell Biochem. 2018;89:261-285. doi: 10.1007/978-981-13-2233-4_11.
• Unraveling of the Structure and Function of Peroxisomal Protein Import Machineries.
  Kalel VC1, Erdmann R2
  Subcell Biochem. 2018;89:299-321. doi: 10.1007/978-981-13-2233-4_13.

2017

• Dissection of membrane-binding and –remodeling regions in two classes of bacterial phopholipid N-methyltransferases.
  Danne L, Aktas M, Grund N, Bentler T, Erdmann R, Narberhaus F
  Biochim Biophys Acta 1859 (12), 2279-88 2017
• Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.
  Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R
  Microb Cell 4 (7): 229-232. doi: 10.15698/mic2017.07.581. 2017
• Membrane remodeling by a bacterial phosholipid-methylating enzyme.
  Danne L, Aktas M, Unger A, Linke WA, Erdmann R, Narberhaus F
  MBio 8 (1), pii:e02082-16:10.1128/mBio.02082-16 2017
• Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins.
  Wroblewska JP, Cruz-Zaragoza LD, Wei Y, Schummer A, Chuartzman SG, de Boer R, Oeljeklaus S, Schuldiner M, Zalckvar E, Warscheid B, Erdmann R, van der Klei IJ
  Biochim Biophys Acta. 2017 pii: S0167- 4889 (17): 1656-67. 30146-5. doi: 10.1016/j.bbamcr.2017.05.021.
• Inhibitors of PEX14 disprupt protein import into glycosomes and kill Trypanosoma parasites
  Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM
  Science 355 (6332): 1416-20. doi: 10.1126/science.aal1807 (2017)
• Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
  Emmanouilidis L, Schütz U, Tripsiandes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M
  Nat Commun 8 14635.doi:10.1038/ncomms14635 (2017)
• ATP-driven processes of peroxisomal matrix protein import
  Schwerter D, Grimm I, Platta HW, Erdmann R
  Biol Chem 398 (5-6), 607-24 (2017)
• In cellulo approaches to study peroxisomal protein import – yeast immunofluorescence microscopy
  Hansen T, Girzalsky W, Erdmann R
  In Peroxisomes Volume 1595, Methods in Molecular Biology. Springer Verlag pp 191-96 (2017)
• Isolation of native soluble.
  Hansen T, Chan A, Schröter T, Schwerter D, Girzalky W, Erdmann R
  In Peroxisomes Volume 1595, Methods in Molecular Biology. Springer Verlag pp 47-44

2016

• Why do peroxisomes associate with the cytoskeleton?
  Neuhaus A, Eggeling C, Erdmann R, Schliebs W
  Biochim Biophys Acta 1863 (5), 1019-26 (2016)
• Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal proteinimport machinery.
  Chan A, Schummer A, Fischer S, Schröter T, Cruz-Zaragoza LD, Bender J, Drepper F, Oeljeklaus S, Kunau WH, Girzalsky W, Warscheid B, Erdmann R
  Eur J Cell Biol 12 :585-97. doi: 10.1016/j.ejcb.2016.10.004 (2016)
• Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins.
  Effelsberg D, Cruz-Zaragoza LD, Schliebs W, Erdmann R
  J Cell Sci 129 (21):4057-66 (2016)
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
  Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Erdmann R et al.
  Autophagy 12 (1), 1-222 (2016)
• Nucleotide-dependent assembly of the peroxisomal receptor export complex
  Grimm I, Saffian D, Girzalsky W, Erdmann R
  Sci Rep 5 doi: 10.1038/srep19838 2016
• Super resolution microscopy reveals compartmentalization of peroxisomal membrane proteins
  Galiani S, Waithe D, Reglinski K, Cruz-Zaragoza LD, Garcia E, Clausen MP, Schliebs W, Erdmann R, Eggeling
  J Biol Chem pii, 291 (33):16948-62. doi: 10.1074/jbc.M116.734038. 2016
• Assembly, maintenance and dynamics of peroxisomes
  Erdmann R
  Biochim Biophys Acta 2016, Review
• Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.
  Mindthoff S1, Grunau S2, Steinfort LL1, Girzalsky W1, Hiltunen JK2, Erdmann R3, Antonenkov VD4
  Biochim Biophys Acta. 2016 Feb;1863(2):271-83. doi: 10.1016/j.bbamcr.2015.11.013. Epub 2015 Nov 17
• Role of AAA+-proteins in peroxisome biogenesis and function.
  Grimm I1, Erdmann R2, Girzalsky W3
  Biochim Biophys Acta. 1863 (5), 828-37 2016

2015

• Role of Pex21p for piggyback import of Gpd1p and Pnc1p into peroxisomes of Saccharomyces cerevisiae.
  Effelsberg D, Cruz-Zaragoza LD, Tonillo J, Schliebs W, Erdmann R.
  J Biol Chem. 2015 Aug 15. pii: jbc.M115.653451. 290 (42), 25333-42.
• Distinct Pores for Peroxisomal Import of PTS1 and PTS2 Proteins.
  Montilla-Martinez M1, Beck S2, Klümper J2, Meinecke M3, Schliebs W2, Wagner R4, Erdmann R5
  Cell Rep. 2015 Dec 15 13(10):2126-34. doi: 10.1016/j.celrep.2015.11.016. Epub 2015 Dec 7
• Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2.
  Reglinski K1, Keil M1, Altendorf S1, Waithe D2, Eggeling C2, Schliebs W1, Erdmann R
  PLoS One. 2015 Oct 20;10(10):e0140685. doi: 10.1371/journal.pone.0140685. eCollection 2015.
• Identification and functional characterization of Trypanosoma brucei peroxin 16.
  Kalel VC, Schliebs W, Erdmann R.
  Biochim Biophys Acta 1853, 2326-37. 2015
• Molecular snapshots of the Pex1/6 AAA+ complex in action.
  Ciniawsky S, Grimm I, Saffian D, Girzalsky W, Erdmann R, Wendler P.
  Nat Commun. 2015 Jun 12;6:7331. doi: 10.1038/ncomms8331.
• Isolation of Peroxisomes from Yeast.
  Cramer J, Effelsberg D, Girzalsky W, Erdmann R.
  Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.top074500. doi: 10.1101/pdb.top074500.
• Large-Scale Purification of Peroxisomes for Preparative Applications.
  Cramer J, Effelsberg D, Girzalsky W, Erdmann R.
  Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.prot083725. doi: 10.1101/pdb.prot083725.
• Small-Scale Purification of Peroxisomes for Analytical Applications.
  Cramer J, Effelsberg D, Girzalsky W, Erdmann R.
  Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.prot083717. doi: 10.1101/pdb.prot083717
• Structural insights into cargo recognition by the yeast PTS1-receptor.
  Hagen, S., Drepper, F., Fischer, S., Fodor, K., Passon, D., Platta, H.W., Zenn, M., Schliebs, W., Girzalsky, W., Wilmanns, M., Warscheid, B. & Erdmann, R.
  J. Biol. Chem. pii: jbc.M115.657973 290 (44), 26610-26 (2015)
• Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation.
  Schwartzkopff, B., Platta, H.W., Hasan, S., Girzalsky, W. & Erdmann, R.
  Biosci. Rep. (in press) 35(3). pii: e00215 (2015)
• Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
  Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M.
  Traffic. 16(1) 85-98; 2015 Jan

2014

• The peroxisomal exportomer
  Platta HW, Hagen S, Erdmann R
  In Brocard C & Hartig , A (eds) Molecular machines involved in peroxisome biogenesis and maintenance/ Springer Verlag Chapter 15, 347-70
• The matrix protein import complex
  Effelsberg D, Erdmann R, Schliebs W
  In Brocard C & Hartig , A (eds) Molecular machines involved in peroxisome biogenesis and maintenance/ Springer Verlag. Chapter 13, 305-23 (2014)
• The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor
  El Magraoui F, Schrötter A, Brinkmeier R, Kunst L, Mastalski T, Müller T, Marcus K, Meyer HE, Girzalsky W, Erdmann R, Platta HW.
  PLoS One. 9(8) e105894; 2014 Aug
• Small cationic antimicrobial peptides delocalize peripheral membrane proteins
  Wenzel M, Chiriac AI, Otto A, Zweytick D, May C, Schumacher C, Gust R, Albada HB, Penkova M, Krämer U, Erdmann R, Metzler-Nolte N, Straus SK, Bremer E, Becher D, Brötz-Oesterhelt H, Sahl HG, Bandow JE
  Proc Natl Acad Sci USA.111(14) E1409-18; 2014 Apr
• Evolving models for peroxisome biogenesis
  Hettema EH, Erdmann R, van der Klei I, Veenhuis M.
  Curr Opin Cell Biol. 29 25-30; 2014 Aug
• The peroxisomal receptor dislocation pathway: to the exportomer and beyond.
  Platta HW, Hagen S, Reidick C, Erdmann R.
  Biochemie 98 16-28; 2014 Mar
• Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
  Nensa FM, Neumann MH, Schrötter A, Przyborski A, Mastalski T, Susdalzew S, Looβe C, Helling S, El Magraoui F, Erdmann R, Meyer HE, Uszkoreit J, Eisenacher M, Suh J, Guénette SY, Röhner N, Kögel D, Theiss C, Marcus K, Müller T.
  Mol Cell Proteomics.13(2) 475-88; 2014 Feb
• A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
  Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R.
  J Biol Chem. 289 (1) 437-48, 2014 Jan 3

2013

• Correction: The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey.
  Gronemeyer T, Wiese S, Ofman R, Bunse C, Pawlas M, Hayen H, Eisenacher M, Stephan C, Meyer HE, Waterham HR, Erdmann R, Wanders RJ, Warscheid B.
  PLoS One. 8 (10) 2013 Oct 16
• Import of proteins into the peroxisomal matrix.
  Hasan S, Platta HW, Erdmann R.
  Front Physiol. 4:261 eCollection 2013 Sep 24
• Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p.
  El Magraoui F, Brinkmeier R, Schrötter A, Girzalsky W, Müller T, Marcus K, Meyer HE, Erdmann R, Platta HW.
  Traffic.14 (12) 1290-301; 2013 Dec
• Give what you can and keep what you need!
  Girzalsky W, Erdmann R.
  EMBO J. 32 (18) 2424-6; 2013 Sep 11
• A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for ER reticulon homology proteins in peroxisome biogenesis.
  David C, Koch J, Oeljeklaus S, Laernsack A, Melchior S, Wiese S, Schummer A, Erdmann R, Warscheid B, Brocard C.
  Mol Cell Proteomics. 12 (9) 2408-25; 2013 Sep
• FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
  Schrötter A, Mastalski T, Nensa FM, Neumann M, Loosse C, Pfeiffer K, Magraoui FE, Platta HW, Erdmann R, Theiss C, Uszkoreit J, Eisenacher M, Meyer HE, Marcus K, Müller T.
  J Cell Sci. 126 (Pt 11) 2480-92; 2013 Jun 1
• The proteome of human liver peroxisomes: identification of five new peroxisomal constituents by a label-free quantitative proteomics survey.
  Gronemeyer T, Wiese S, Ofman R, Bunse C, Pawlas M, Hayen H, Eisenacher M, Stephan C, Meyer HE, Waterham HR, Erdmann R, Wanders RJ, Warscheid B.
  PLoS One. 8 (2) e57395; 2013
• The exportomer: the peroxisomal receptor export machinery.
  Platta HW, Hagen S, Erdmann R.
  Cell Mol Life Sci. 70 (8) 1393-411; 2013 Apr

2012

• The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.
  Schrötter A, Pfeiffer K, El Magraoui F, Platta HW, Erdmann R, Meyer HE, Egensperger R, Marcus K, Müller T.
  Mol Cell Proteomics. 11 (11) 1274-88; 2012 Nov;
• Edgetic perturbations set phenotypic variability in PBD
  Lotz-Havla AS, Woidy M, Guder P, Erdmann R, Muntau AC, Gersting SW
  European Journal of Pediatrics Volume 9 1421-31; September 2012
• The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.
  Schrötter A, Pfeiffer K, El Magraoui F, Platta H, Erdmann R, Meyer HE, Egensperger R, Marcus K, Müller T.
  Mol Cell Proteomics. 11 (11) 1274-88; 2012 Nov
• TubStain: a universal peptide-tool to label microtubules.
  Theiss C, Neuhaus A, Schliebs W, Erdmann R.
  Histochem Cell Biol. 138 (3), Epub 2012 Jul 6 531-40, 2012 Sep
• ATP-dependent assembly of the heteromeric Pex1p-Pex6p-complex of the peroxisomal matrix protein import machinery.
  Saffian D, Grimm I, Girzalsky W, Erdmann R.
  J Struct Biol. 179 (2) 2012 Aug; 126-32
• Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import.
  Nagotu S, Kalel VC, Erdmann R, Platta HW.
  Biochim Biophys Acta. 1822 (9) 2012 Sep: 1326-36
• Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.
  Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M.
  PLoS Biol. 10 (4) e1001309, 1 - 12, 2012
• Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.
  Otzen M, Ruckt R, Thoms S, Emmrich K, Krikken AM, Erdmann R, van der Klei IJ.
  Traffic. 13 (7) 947-59; 2012 Apr 10
• Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis.
  Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B.
  J Proteome Res. 11 (4) 2012 Apr 6; 2567-80
• The RING-type ubiquitin-ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an E2-selective manner.
  El Magraoui F, Bäumer BE, Platta HW, Baumann JS, Girzalsky W, Erdmann R.
  FEBS J. 279 (11) 2060-70; 2012 Jun
• AAA ATPases: Structure and function.
  Erdmann R.
  Biochim Biophys Acta. 1823 (1) 2011 Dec 14.
• The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae.
  Grimm I, Saffian D, Platta HW, Erdmann R.
  Biochim Biophys Acta. 1823 (1) 150-58; 2012 Jan

2011

• Role for cER and Mmr1p in Anchorage of Mitochondria at Sites of Polarized Surface Growth in Budding Yeast.
  Swayne TC, Zhou C, Boldogh IR, Charalel JK, McFaline-Figueroa JR, Thoms S, Yang C, Leung G, McInnes J, Erdmann R, Pon LA.
  Curr Biol. 21 1-6; 2011 December 6
• Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane.
  Hensel A, Beck S, El Magraoui F, Platta HW, Girzalsky W, Erdmann R.
  J Biol Chem. 286 (50) 43495-505, 2011 Oct 23.
• A monoclonal antibody for in vivo detection of peroxisome-associated PTS1 receptor.
  Cizmowski C, Jung M, Erdmann R, Schliebs W.
  Hybridoma (Larchmt). 30 (4) 2011 Aug; 387-91
• Ubp15p, an ubiquitin hydrolase associated with the peroxisomal export machinery.
  Debelyy MO, Platta HW, Saffian D, Hensel A, Thoms S, Meyer HE, Warscheid B, Girzalsky W, Erdmann R.
  J Biol Chem. 286(32) 28223-34; 2011 Aug 12
• The putative yeast hydrolase Ldh1p is localized to Lipid droplets.
  Thoms S, Debelyy MO, Connerth M, Daum G, Erdmann R.
  Eukaryot Cell. 10 (6) 776-81; 2011 Jun
• Involvement of the yeast hydrolase Ldh1p in lipid homeostasis.
  Debelyy MO, Thoms S, Connerth M, Daum G, Erdmann R.
  Eukaryot Cell. 10 (6) 776-81; 2011 Jun
• Pex 14 is required for microtubule-based peroxisome motility in human cells
  Bahrti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrman C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R
  J Cell Sci. 124 (10) 1759-1768; 2011 May 15
• Protein import machineries of peroxisomes.
  Rucktäschel R, Girzalsky W, Erdmann R.
  Biochim Biophys Acta 1808 (3) 892-900; 2011 Mar
• The peroxisomal targeting signal 1 in sterol carrier 2 is autonomous and essential for receptor recognition
  Williams C P, Schueller N, Thompson C A, van den Berg M, van Haren S D, Erdmann R, Bond C S, Distel B, Schliebs W, Wilmanns M, Stanley W A
  BMC Biochem. 12 12, 2011 Mar 4
• Theta-burst transcranial magnetic stimulation alters cortical inhibition.
  Benali A, Trippe J, Weiler E, Mix A, Petrasch-Parwez E, Girzalsky W, Eysel UT, Erdmann R, Funke K.
  J Neurosci. 31 (4) 1193-203; 2011 Jan 26
• The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae
  Grunau S, Lay D, Mindthoff S, Platta HW, Girzalsky W, Just WW, Erdmann R.
  Biochem J. 434 (1) 161-70; 2011 Jan 27

2010

• Proteinimport in die peroxisomale Matrix – ein Prozess nimmt Form an
  Hensel, A, Girzalsky, W, Erdmann, R
  Biospektrum 04/10 395 - 397; 2010
• Peroxisomal protein import and ERAD: variations on a common theme
  Schliebs W, Girzalsky W, Erdmann R.
  Nat Rev Mol Cell Biol. 11 (12) 885-890; 2010 Dec
• Peroxisomes as dynamic organelles: peroxisomal matrix protein import.
  Wolf J, Schliebs W, Erdmann R.
  FEBS J. 277 (16) 3268-78; 2010 Aug
• The peroxisomal receptor Pex19p forms a helical mPTS recognition domain
  Schueller N, Holton SJ, Fodor K, Milewski M, Konarev P, Stanley WA, Wolf J, Erdmann R, Schliebs W, Song YH, Wilmanns M.
  EMBO J. 29 (15) 2491-500; 2010 Aug 4
• De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p.
  Rucktäschel R, Halbach A, Girzalsky W, Rottensteiner H, Erdmann R.
  Eur J Cell Biol. 89 (12) 947-54; 2010 Dec
• Identification of PEX33, a novel component of the peroxisomal docking complex in the filamentous fungus Neurospora crassa.
  Managadze D, Würtz C, Wiese S, Schneider M, Girzalsky W, Meyer HE, Erdmann R, Warscheid B, Rottensteiner H.
  Eur J Cell Biol 89 (12) 955-64; 2010 Dec
• A proteomic approach towards the identification of the matrix protein content of the two types of microbodies in Neurospora crassa.
  Managadze D, Würtz C, Wiese S, Meyer HE, Niehaus G, Erdmann R, Warscheid B, Rottensteiner H.
  Proteomics. 10 (18) 3222-34; 2010 Sep
• Targeting of Pex8p to the peroxisomal importomer
  Deckers M, Emmrich K, Girzalsky W, Awa WL, Kunau WH, Erdmann R.
  Eur J Cell Biol. 89 (12) 924-31; 2010 Dec
• Peroxisomal protein translocation
  Girzalsky W, Saffian D, Erdmann R.
  Nat Cell Biol. Biochim Biophys Acta Nat Cell Biol.
• The peroxisomal importomer constitutes a large and highly dynamic pore.
  Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R.
  Nat Cell Biol. 12 (3) 273-7; 2010 Mar

2009

• An involvement of yeast peroxisomal channels in transmembrane transfer of glyoxylate cycle intermediates
  Antonenkov VD, Mindthoff S, Grunau S, Erdmann R, Hiltunen JK.
  Int J Biochem Cell Biol. 41 (12) 2546-54; 2009 Dec
• Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import.
  Platta HW, El Magraoui F, Bäumer BE, Schlee D, Girzalsky W, Erdmann R.
  Mol Cell Biol. 29 (20) 5505-16; 2009 Oct
• The N-domain of Pex22p can functionally replace the Pex3p N-domain in targeting and peroxisome formation
  Halbach A, Rucktäschel R, Rottensteiner H, Erdmann R.
  J Biol Chem. 284 (6) 3906-16; 2009 Feb 6
• Protein transport across the peroxisomal membrane
  Girzalsky W, Platta HW, Erdmann R.
  Biol Chem. 390 (8) 745-51; 2009 Aug
• Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis
  Rucktäschel R, Thoms S, Sidorovitch V, Halbach A, Pechlivanis M, Volkmer R, Alexandrov K, Kuhlmann J, Rottensteiner H, Erdmann R.
  J Biol Chem. 284 (31) J Biol Chem.
• Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae
  Grunau S, Mindthoff S, Rottensteiner H, Sormunen RT, Hiltunen JK, Erdmann R, Antonenkov VD.
  FEBS J. 276 (6) 1698-708; 2009 Mar
• Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19
  Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M.
  EMBO J. 28 (6) 745-54; 2009 Mar 18
• Peroxisomal targeting of PTS2 pre-import complexes in the yeast Saccharomyces cerevisiae.
  Grunau S, Schliebs W, Linnepe R, Neufeld C, Cizmowski C, Reinartz B, Meyer HE, Warscheid B, Girzalsky W, Erdmann R.
  Traffic. 10 (4) 451-60; 2009 Apr
• The Woronin body as a peroxisome with a function in the maintenance of cellular integrity
  Christian Würtz, Wolfgang Schliebs, Ralf Erdmann and Hanspeter Rottensteiner
  Research Signpost 37/661, ISBN 978-81-308-0344-9 43 - 59; 2009

2008

• Intracellular compartments and protein sorting.
  Aitchison J, Erdmann R, Gerace L, Hegde R, Hetzer MW, MCNew JA, Pfanner N, Rehling P, Rout M, Schnell DJ, Schuck S, Subramani S, Voeltz G, Wente SR
  In Molecular Biology of the Cell Sixth Edition Chapter 12, pp 641-94 (2008)
• Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein.
  Würtz C, Schliebs W, Erdmann R, Rottensteiner H.
  FEBS J. 275 (11) 2932-41; 2008 Jun
• The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p.
  Platta HW, Debelyy MO, El Magraoui F, Erdmann R.
  Biochem Soc Trans. 36 (Pt 1) 99-104; 2008 Feb
• Lpx1p is a peroxisomal lipase required for normal peroxisome morphology.
  Thoms S, Debelyy MO, Nau K, Meyer HE, Erdmann R.
  FEBS J. 275 (3) 504-14; 2008 Feb

2007

• Peroxisomal dynamics.
  Platta HW, Erdmann R.
  Trends Cell Biol. 17 (10) 474-84; 2007 Oct
• Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
  Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJ, Warscheid B.
  Mol Cell Proteomics. 6 (12) 2045-57; 2007 Dec
• Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes.
  Saveria T, Halbach A, Erdmann R, Volkmer-Engert R, Landgraf C, Rottensteiner H, Parsons M.
  Eukaryot Cell. 6 (8) 1439-49, 2007 Aug
• Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling.
  Platta HW, El Magraoui F, Schlee D, Grunau S, Girzalsky W, Erdmann R.
  J Cell Biol. 177 (2) 197-204; 2007 Apr 23
• The peroxisomal protein import machinery.
  Platta HW, Erdmann R.
  FEBS Lett. 581 (15) 2811-9; 2007 Jun 19
• Function of the Ubiquitin-Conjugating Enzyme Pex4p and the AAA Peroxin Complex Pex1p/Pex6p in Peroxisomal Matrix Protein Transport
  Harald W. Platta, Sven Thoms, Wolf-H. Kunau and Ralf Erdmann
  The Enzymes, Elsevier Volume 25 541-572; 2007
• Characterisation of zinc-binding domains of peroxisomal RING finger proteins using size exclusion chromatography/inductively coupled plasma-mass spectrometry.
  Koellensperger G, Daubert S, Erdmann R, Hann S, Rottensteiner H.
  Biol Chem. 388 (11) Biol Chem.

2006

• Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
  Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M.
  Mol Cell. 24 (5) 653-63; 2006 Dec 8
• Peroxisomal matrix protein receptor ubiquitination and recycling.
  Thoms S, Erdmann R.
  Biochim Biophys Acta. 1763 (12) 1620-8; 2006 Dec
• Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae.
  Kuravi K, Nagotu S, Krikken AM, Sjollema K, Deckers M, Erdmann R, Veenhuis M, van der Klei IJ.
  J Cell Sci. 119 (Pt 19) 3994-4001; 2006 Oct 1
• Functional association of the AAA complex and the peroxisomal importomer.
  Rosenkranz K, Birschmann I, Grunau S, Girzalsky W, Kunau WH, Erdmann R.
  FEBS J. 273 (16) 3804-15; 2006 Aug
• Investigation of peroxisome biogenesis revealed possible new roles for autophagy components.
  Heiland I, Erdmann R.
  Autophagy. 2 (3) 209-11; 2006 Jul-Sep
• Membrane association of the cycling peroxisome import receptor Pex5p.
  Kerssen D, Hambruch E, Klaas W, Platta HW, de Kruijff B, Erdmann R, Kunau WH, Schliebs W.
  J Biol Chem. 281 (37) 27003-15; Sep 15 2006
• Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites.
  Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H.
  J Cell Sci. 2006 Jun 15 2508-17; 119 (Pt 12)
• Pex19p-dependent targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery.
  Girzalsky W, Hoffmann LS, Schemenewitz A, Nolte A, Kunau WH, Erdmann R.
  J Biol Chem. 281 (28) 19417-25; 2006 Jul 14

2005

• Topogenesis of peroxisomal proteins does not require a functional cytoplasm-to-vacuole transport.
  Heiland I, Erdmann R.
  Eur J Cell Biol. 84 (10) 799-807; 2005 Oct
• Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.
  Thoms S, Erdmann R.
  FEBS J. 272 (20) 5169-81; 2005 Oct
• Import of Proteins into Peroxisomes
  Sven Thoms and Ralf Erdmann
  Landes Bioscience ISBN: 978-0-387-25758-7 324 - 328; Oct. 2005
• Peroxisomal matrix protein import: the transient pore model.
  Erdmann R, Schliebs W.
  Nat Rev Mol Cell Biol. 6 (9) 738-42; 2005 Sep
• Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.
  Platta HW, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R.
  Nat Cell Biol. 7 (8) 817-22; 2005 Aug
• Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins.
  Heiland I, Erdmann R.
  FEBS J. 272 (10) 2362-72; 2005 May
• Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import.
  Schell-Steven A, Stein K, Amoros M, Landgraf C, Volkmer-Engert R, Rottensteiner H, Erdmann R.
  Mol Cell Biol. 25 (8) 3007-18; 2005 Apr
• Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved.
  Halbach A, Lorenzen S, Landgraf C, Volkmer-Engert R, Erdmann R, Rottensteiner H.
  J Biol Chem. 280 (22) 21176-82; 2005 Jun 3
• Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p.
  Birschmann I, Rosenkranz K, Erdmann R, Kunau WH.
  FEBS J. 272 (1) 47-58; 2005 Jan

2004

• Ubiquitination of the peroxisomal import receptor Pex5p.
  Platta HW, Girzalsky W, Erdmann R.
  Biochem J. 384 (Pt 1) 37-45; 2004 Nov 15
• The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in DeltapH formation across peroxisomal membranes.
  Lasorsa FM, Scarcia P, Erdmann R, Palmieri F, Rottensteiner H, Palmieri L.
  Biochem J. 381 (Pt 3) 581-5, 2004 Aug 1
• Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals.
  Rottensteiner H, Kramer A, Lorenzen S, Stein K, Landgraf C, Volkmer-Engert R, Erdmann R.
  Mol Biol Cell. 15 (7) 3406-17, 2004 Jul

2003

• Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis
  Rottensteiner H, Stein K, Sonnenhol E, Erdmann R.
  Mol Biol Cell. 14 (10) 4316-28; 2003 Oct
• Saccharomyces cerevisiae PIP2 mediating oleic acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p.
  Rottensteiner H, Wabnegger L, Erdmann R, Hamilton B, Ruis H, Hartig A, Gurvitz A.
  J Biol Chem. 278 (30) 27605-11; 2003 Jul 25
• Peroxisomenbiogenese:Peroxine und Präimplexe
  Thoms S, Erdmann R
  Biospektrum 3 269 - 271; 2003
• Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE.
  Rottensteiner H, Hartig A, Hamilton B, Ruis H, Erdmann R, Gurvitz A.
  Eur J Biochem. 270 (9) 2013-22; 2003 May
• Peroxisome biogenesis.
  Eckert JH, Erdmann R.
  Rev Physiol Biochem Pharmacol. 147 75-121; 2003
• The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p.
  Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R.
  J Mol Biol. 326 (5) 1427-35; 2003 Mar 7

2002

• Interactions of Pex7p and Pex18p/Pex21p with the peroxisomal docking machinery: implications for the first steps in PTS2 protein import.
  Stein K, Schell-Steven A, Erdmann R, Rottensteiner H.
  Mol Cell Biol. 22 (17) 6056-69; 2002 Sep
• Visualization and purification of yeast peroxisomes.
  Erdmann R, Gould SJ.
  Methods Enzymol. 351 365-81; 2002
• The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction.
  Rottensteiner H, Palmieri L, Hartig A, Hamilton B, Ruis H, Erdmann R, Gurvitz A.
  Biochem J. 365 (Pt 1) 109-17; 2002 Jul

2001

• Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter
  Palmieri L, Rottensteiner H, Girzalsky W, Scarcia P, Palmieri F, Erdmann R.
  EMBO J. 20 (18) 5049-59; 2001 Sep 17
• Identification of peroxisomal membrane proteins of Saccharomyces cerevisiae by mass spectrometry.
  Schäfer H, Nau K, Sickmann A, Erdmann R, Meyer HE.
  Electrophoresis. 2001 Aug 22 (14) 2955-68; 2001 Aug
• Protein translocation machineries of peroxisomes.
  Holroyd C, Erdmann R.
  FEBS Lett. 501 (1) 6-10; 2001 Jul 13
• Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11.
  Gurvitz A, Hiltunen JK, Erdmann R, Hamilton B, Hartig A, Ruis H, Rottensteiner H.
  J Biol Chem. 276 (34) 31825-30; 2001 Aug 24

2000

• Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p.
  Rehling P, Skaletz-Rorowski A, Girzalsky W, Voorn-Brouwer T, Franse MM, Distel B, Veenhuis M, Kunau WH, Erdmann R.
  J Biol Chem. 275 (5) 3593-602; 2000 Feb 4
• Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins.
  Hettema EH, Girzalsky W, van Den Berg M, Erdmann R, Distel B.
  EMBO J. 19 (2) 223-33; 2000 Jan 17

1999

• Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
  Geisbrecht BV, Schulz K, Nau K, Geraghty MT, Schulz H, Erdmann R, Gould SJ.
  Biochem Biophys Res Commun. 260 (1) 28-34; 1999 Jun 24
• Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum.
  Warnecke D, Erdmann R, Fahl A, Hube B, Müller F, Zank T, Zähringer U, Heinz E.
  J Biol Chem. 274 (19) 13048-59; 1999 May 7
• Identification of peroxisomal acyl-CoA thioesterases in yeast and humans.
  Jones JM, Nau K, Geraghty MT, Erdmann R, Gould SJ.
  J Biol Chem. 274 (14) 9216-23; 1999 Apr 2
• Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes.
  Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R.
  J Cell Biol. 144 (6) 1151-62; 1999 Mar 22
• Identification and characterization of the human orthologue of yeast Pex14p.
  Will GK, Soukupova M, Hong X, Erdmann KS, Kiel JA, Dodt G, Kunau WH, Erdmann R.
  Mol Cell Biol. 19 (3) 2265-77; 1999 Mar

1998

• Molecular characterization of Saccharomyces cerevisiae Δ3, Delta2-enoyl-CoA isomerase.
  Geisbrecht BV, Zhu D, Schulz K, Nau K, Morrell JC, Geraghty M, Schulz H, Erdmann R, Gould SJ.
  J Biol Chem. 273 (50) 33184-91; 1998 Dec 11
• Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p.
  Lorenz P, Maier AG, Baumgart E, Erdmann R, Clayton C.
  EMBO J. 17 (13) 3542-55; 1998 Jul 1
• Peroxisome biogenesis: back to the endoplasmic reticulum?
  Kunau WH, Erdmann R.
  Curr Biol. 8 (9) R299-302; 1998 Apr 23
• IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids.
  Henke B, Girzalsky W, Berteaux-Lecellier V, Erdmann R.
  J Biol Chem. 273 (6) 3702-11; 1998 Feb 6
• Pex19p, a farnesylated protein essential for peroxisome biogenesis.
  Götte K, Girzalsky W, Linkert M, Baumgart E, Kammerer S, Kunau WH, Erdmann R.
  Mol Cell Biol. 18 (1) 616-28; 1998 Jan

1997

• Peroxisomes: Organelles at the crossroads.
  Erdmann R, Veenhuis M, Kunau WH.
  Trends Cell Biol. 7 (10) 400-7; 1997 Oct
• Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways.
  Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH.
  Cell. 89 (1) 83-92; 1997 Apr 4
• Protein import into peroxisomes
  Erdmann R, Kunau WH
  Schenk HEA, Herrman R, Jeon KW, Müller NE, Schwemmler W (eds), Springer Verlag Berlin Eukaryotism and Symbiosis 195 - 205

1996

• Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor.
  Erdmann R, Blobel G.
  J Cell Biol. 135 (1) 111-21; 1996 Oct
• A unified nomenclature for peroxisome biogenesis factors.
  Distel B, Erdmann R, Gould SJ, Blobel G, Crane DI, Cregg JM, Dodt G, Fujiki Y, Goodman JM, Just WW, Kiel JA, Kunau WH, Lazarow PB, Mannaerts GP, Moser HW, Osumi T, Rachubinski RA, Roscher A, Subramani S, Tabak HF, Tsukamoto T, Valle D, van der Klei I, van Veldhoven PP, Veenhuis M.
  J Cell Biol. 135 (1) 1-3; 1996 Oct
• Identification of a yeast peroxisomal member of the family of AMP-binding proteins.
  Blobel F, Erdmann R.
  Eur J Biochem. 240 (2) 468-76; 1996 Sep 1

1995

• Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p.
  Erdmann R, Blobel G.
  J Cell Biol. 128 (4) 509-23; 1995 Feb

1994

• Effect of site-directed mutagenesis of conserved lysine residues upon Pas1 protein function in peroxisome biogenesis.
  Krause T, Kunau WH, Erdmann R.
  Yeast. 10 (12) 1613-20; 1994 Dec
• PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes.
  Marzioch M, Erdmann R, Veenhuis M, Kunau WH.
  EMBO J. 13 (20) 4908-18; 1994 Oct 17
• The 2.8 A crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha beta alpha beta alpha structure constructed from two core domains of identical topology.
  Mathieu M, Zeelen JP, Pauptit RA, Erdmann R, Kunau WH, Wierenga RK.
  Structure. 2 (9) 797-808; 1994 Sep 15
• Purification and immunolocalization of the peroxisomal 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae.
  Erdmann R, Kunau WH.
  Yeast. 10 (9) 1173-82; 1994 Sep
• The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae.
  Erdmann R.
  Yeast. 10 (7) 935-44; 1994 Jul

1992

• A genetic approach to the biogenesis of peroxisomes in the yeast Saccharomyces cerevisiae.
  Erdmann R, Kunau WH.
  Cell Biochem Funct. 10 (3) 167-74; 1992 Sep
• Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product.
  Hiltunen JK, Wenzel B, Beyer A, Erdmann R, Fosså A, Kunau WH.
  J Biol Chem. 267 (10) 6646-53; 1992 Apr 5

1991

• Regulation of transcription of the gene coding for peroxisomal 3-oxoacyl-CoA thiolase of Saccharomyces cerevisiae.
  Einerhand AW, Voorn-Brouwer TM, Erdmann R, Kunau WH, Tabak HF.
  Eur J Biochem. 200 (1) 6113-22; 1991 Aug 15
• Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.
  Fröhlich KU, Fries HW, Rüdiger M, Erdmann R, Botstein D, Mecke D.
  J Cell Biol. 114 (3) 443-53; 1991 Aug
• PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases.
  Erdmann R, Wiebel FF, Flessau A, Rytka J, Beyer A, Fröhlich KU, Kunau WH.
  Cell. 64 (3) 499-510; 1991 Feb 8

1990

• Crystallographic studies of 3-ketoacylCoA thiolase from yeast Saccharomyces cerevisiae.
  Zeelen JP, Wierenga RK, Erdmann R, Kunau WH.
  J Mol Biol. 215 (2) 211-3; 1990 Sep 20

1989

• Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae.
  Erdmann R, Veenhuis M, Mertens D, Kunau WH.
  Proc Natl Acad Sci U S A. 86 (14) 5419-23;1989 Jul

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