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Faculty of Medicine » Biochemistry and Pathobiochemistry » Systems Biochemistry » BICTP

Dr. rer. nat. Harald W. Platta (Alumni)

2024

• ATP-dependent steps in peroxisomal protein import.
  Platta H.W., Jeske J., Schmidt N. & Erdmann R.
  Annu. Rev. Biochem. 93(1):233-259 (2024)

2023

• Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes.
  Fischer S., Bürgi J., Gabay-Maskit S., Maier R., Mastalski T., Yifrach E., Obarska-Kosinska A., Rudowitz M., Erdmann R., Platta H.W., Wilmanns M., Schuldiner M., Zalckvar E., Oeljeklaus S., Drepper F. & Warscheid B.
  Biol. Chem. 404(2-3):135-155 (2023)

2022

• Structure and activity of the UBC peroxin complex in Arabidopsis thaliana. - Review of the Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane.
  Platta H.W.
  Qeios, 24EP9L (2022)
• The ides of MARCH5: The E3 ligase essential for peroxisome degradation by pexophagy.
  Platta H.W. & Erdmann R.
  J. Cell Biol. 221(1), e202111008 (2022)

2021

• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
  Klionsky et al. [Autophagy Author Consortium]
  Autophagy 17(1), 1-382 (2021)

2020

• Autophagy stimulus-dependent role of the small GTPase Ras2 in peroxisome degradation.
  Boutouja F. & Platta H.W.
  Biomolecules 10(11), 1533 (2020)
• Fluidity and lipid composition of membranes of peroxisomes, mitochondria and the ER from oleic acid-induced Saccharomyces cerevisiae
  Reglinski K., Steinfort L.L., Sezgin E., Klose C., Platta H.W., Girzalsky G., Eggeling C. & Erdmann, R.
  Front. Cell Dev. Biol. 8:574363 (2020)
• The peroxisomal PTS1-Import defect of PEX1-deficient cells is independent of pexophagy in Saccharomyces cerevisiae.
  Mastalski T., Brinkmeier R. & Platta H.W.
  Int. J. Mol. Sci. 21(3), 867 Int. J. Mol. Sci.
• The novel peroxin Pex37: the Pxmp2-family joins the peroxisomal fission machinery.
  Platta. H.W. & Erdmann R.
  FEBS J. 287(9) 1737-1741 (2020)

2019

• Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner.
  Boutouja F., Stiehm C.M., Mastalski T., Brinkmeier R., Reidick C., El Magraoui F. & Platta H.W.
  Sci. Rep. 9(1), 10557 (2019)
• Vac8 controls vacuolar membrane dynamics during different autophagy pathways in Saccharomyces cerevisiae.
  Boutouja F., Stiehm C.M., Reidick C., Mastalski T., Brinkmeier R., El Magraoui F. & Platta H.W.
  Cells 8(7), pii: E661 (2019)
• mTOR: A Cellular Regulator Interface in Health and Disease.
  Boutouja F., Stiehm C.M. & Platta H.W.
  Cells 8(1), pii: E18 (2019)
• The deubiquitination of the PTS1-import receptor Pex5p is required for peroxisomal matrix protein import.
  El Magraoui, F., Brinkmeier, R., Mastalski, T., Hupperich, A., Strehl, C., Schwerter, D., Girzalsky, W., Meyer, H.E., Warscheid, B., Erdmann, R. & Platta, H.W.
  Biochim. Biophys. Acta - Mol. Cell Res. 1866(2), 199-213 (2019)

2017

• Regulation of the tumor-suppressor BECLIN 1 by distinct ubiquitination cascades.
  Boutouja, F. Brinkmeier, R., Mastalski, T., El Magraoui, F. & Platta, H.W.
  Int. J. Mol. Sci. 18 pii: E2541 (2017)
• ATP-driven processes of peroxisomal matrix protein import.
  Schwerter, D., Grimm, I., Platta, H.W. & Erdmann, R.
  Biol. Chem. 398(5-6):607-624
• The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae.
  Reidick, C., Boutouja, F., Platta, H.W.
  Biol. Chem. 398(5-6):677-685

2016

• Regulation of peroxisomal matrix protein import by ubiquitination.
  Platta, H.W., Brinkmeier, R., Reidick, C., Galiani, S., Clausen, M.P. & Eggeling, C.
  Biochim. Biophys. Acta. – Mol. Cell Res. 1863, 838-849 (2016)
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
  Klionsky et al. [Autophagy Author Consortium]
  Autophagy 12, 1-222 (2016)
• Regulation of peroxisome dynamics by phosphorylation.
  Oeljeklaus, S., Schummer, A., Mastalski, T., Platta, H.W. & Warscheid, B.
  Biochim. Biophys. Acta. – Mol. Cell Res. 1863, 1027-1037 (2016)

2015

• Autophagy-related Deubiquitinating Enzymes involved in Health and Disease.
  El Magraoui, F., Reidick, C., Meyer, H.E. & Platta, H.W.
  Cells 4, 596-621 (2015)
• Structural insights into cargo recognition by the yeast PTS1-receptor.
  Hagen, S., Drepper, F., Fischer, S., Fodor, K., Passon, D., Platta, H.W., Zenn, M., Schliebs, W., Girzalsky, W., Wilmanns, M., Warscheid, B. & Erdmann, R.
  J. Biol. Chem. 290, 26610-26626 (2015)
• Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation.
  Schwartzkopff, B., Platta, H.W., Hasan, S., Girzalsky, W. & Erdmann, R.
  Biosci. Rep. 35(3). pii: e00215 (2015)
• Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.
  Reidick, C., El Magraoui, F., Meyer, H.E., Stenmark, H. & Platta, H.W.
  Cancers (Basel) 7, 1-29 (2015)

2014

• The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.
  El Magraoui, F., Schrötter, A., Brinkmeier, R., Kunst, L., Mastalski, T., Müller, T., Marcus, K., Meyer, H.E., Girzalsky, W., Erdmann, R. & Platta, H.W.
  PLoS One 9(8): e 105894 (2014)
• The peroxisomal exportomer.
  Platta, H.W.*, Hagen, S. & Erdmann, R.*
  In: Brocard, C. & Hartig, A. (eds.) Molecular machines involved in peroxisome biogenesis and maintenance / Springer Verlag. (in press) Chapter 15, 347-370 (2014)
• The cycling peroxisomal targeting signal type 1 - receptor Pex5p: reaching the circle`s end with ubiquitin.
  Platta, H.W.
  Receptor. Clin. Invest. 1, 55-68 (2014)
• The peroxisomal receptor dislocation pathway: to the exportomer and beyond.
  Platta, H.W.*, Hagen, S., Reidick, C. & Erdmann, R.*
  Biochimie 98C 16-28 (2014)

2013

• Distinct ubiquitination cascades act on the PTS2-co-receptor Pex18p.
  El Magraoui, F., Brinkmeier, R., Schrötter, A., Girzalsky, W., Müller, T., Marcus, K., Meyer, H.E., Erdmann, R. & Platta, H.W.
  Traffic 14 1290-1301 (2013)
• Import of proteins into the peroxisomal matrix.
  Hasan, S., Platta, H.W.* & Erdmann, R.*
  Front. Physiol. 4, 261 (2013)
• FE65 regulates and interacts to the Bloom syndrome protein in dynamic nuclear spheres – potential relevance to Alzheimer`s disease.
  Schrötter, A., Mastalski, T., Nensa, F.M., Neumann, M., Loosse, C., Pfeiffer, K., El Magraoui, F., Platta, H.W., Erdmann, R., Theiss, C., Uszkoreit, J., Eisenacher, M., Meyer, H.E., Marcus, K. & Müller, T.
  J. Cell Sci. 126, 2480-2492 (2013)
• The exportomer: the peroxisomal receptor export machinery.
  Platta, H.W.*, Hagen, S. & Erdmann, R.*
  Cell. Mol. Life Sci. 70, 1393-1411 (2013)

2012

• The APP family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression - relevance for Alzheimer`s disease.
  Schrötter, A., Pfeiffer, K., El Magraoui, F., Platta, H.W., Erdmann, R., Meyer, H.E., Marcus, K. & Müller, T.
  Mol. Cell. Proteomics 11, 1274-1288 (2012)
• The PtdIns3P-binding protein Phafin2 mediates epidermal growth factor receptor degradation by promoting endosome fusion.
  Pedersen, N.M., Raiborg, C., Brech, A., Skarpen, E., Roxrud, I., Platta, H.W., Liestøl, K. & Stenmark, H.
  Traffic 13, 1547-1563 (2012)
• Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import.
  Nagotu, S., Kalel, V.C., Erdmann, R. & Platta, H.W.
  Biochim. Biophys. Acta – Mol. Basis Dis. 1822, 1326-1336 (2012)
• Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression.
  Abrahamsen, H., Stenmark, H. & Platta, H.W.
  FEBS Lett. 1584-1591 (2012)
• The RING-type ubiquitin-ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner.
  El Magraoui, F., Bäumer, B.E., Platta, H.W., Baumann, J.S., Girzalsky, G., & Erdmann, R.
  FEBS J. 279, 2060-2070 (2012)
• The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae.
  Grimm, E., Saffian, D., Platta, H.W., Erdmann, R.
  Biochim. Biophys. Acta – Mol. Cell Res. 1823, 150-158 (2012)
• Nedd4-dependent lysine-11-linked polyubiquitination of the tumor-suppressor Beclin 1.
  Platta, H.W., Abrahamsen, H., Thoresen, S.B. & Stenmark, H.
  Biochem. J. 441, 399-406 (2012)

2011

• Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane.
  Hensel, A., Beck, S., El Magraoui, F., Platta, H.W., Girzalsky, W. & Erdmann, R.
  J. Biol. Chem. 286, 43495-43505 (2011)
• Ubp15p, an ubiquitin hydrolase associated with the peroxisomal export machinery.
  Debelyy, M.O., Platta, H.W., Saffian, D., Hensel, A., Thoms, S.,Warscheid, B., Meyer, H.E., Girzalsky, G. &
  J. Biol. Chem. 286, 28223-28234 (2011)
• Endocytosis and signaling.
  Platta, H.W.* & Stenmark, H.*
  Curr. Opin. Cell Biol. 23, 393-403 (2011)
• The Phosphoinositide-3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisae.
  Grunau, S., Lay, D., Mindthoff, S., Platta, H.W., Girzalsky, W., Just, W.W. & Erdmann, R.
  Biochem. J. 434, 161-170 (2011)

2009

• Pex2 and Pex12 function as protein-ubiquitin ligases in peroxisomal protein import.
  Platta, H.W.*, El Magraoui, F.*, Bäumer, B.E., Schlee, D., Girzalsky, W. & Erdmann, R.
  Mol. Cell. Biol. 29, 5505-5516 (2009)
• Protein transport across the peroxisomal membrane.
  Girzalsky, W., Platta, H.W. & Erdmann, R.
  Biol. Chem. 390, 745-751 (2009)

2008

• The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p.
  Platta, H.W., Debelyy, M.O., El Magraoui, F. & Erdmann, R.
  Biochem. Soc. Trans. 36, 99-104 (2008)

2007

• Peroxisomal dynamics.
  Platta, H.W. & Erdmann, R.
  Trends Cell Biol. 10, 474-484 (2007)
• Peroxisomal protein translocation machinery.
  Platta, H.W. & Erdmann, R.
  FEBS Lett. 581, 2811-2819 (2007)
• Regulation des Proteinimports in Peroxisomen. Molekularer Mechanismus des Rezeptor-Recyclings.
  Platta, H.W. & Erdmann, R.
  BIOforum 4/07 30-31 (2007)
• Function of the ubiquitin-conjugating enzyme Pex4p and the AAA peroxins Pex1p and Pex6p in peroxisomal protein transport.
  Platta, H.W., Thoms, S., Kunau, W.-H. & Erdmann, R.
  Dalbey, R.E., Koehler, C. & Tamanoi, F. (eds.) The Enzymes Vol. 25, Molecular Machines involved in Protein Transport across Cellular Membranes / Elsevier Academic Press 529-560. (2007)
• Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling.
  Platta, H.W., El Magraoui, F., Schlee, D., Grunau, S., Girzalsky, W. & Erdmann, R.
  J. Cell Biol. 177, 197-204 (2007)

2006

• Meeting report: Life of proteins.
  Platta, H.W., Schliebs, W. & Girzalsky, W.
  Chaperone Newsletter 15, 34-35 (2006)
• Membrane association of the cycling peroxisome import receptor Pex5p.
  Kerssen, D., Hambruch, E., Klaas, W., Platta, H.W., de Kruijff, B., Erdmann, R., Kunau, W.-H. & Schliebs, W.
  J. Biol. Chem. 27003-27015 (2006)

2005

• Functional role of the AAA peroxins in dislocation of the cycling PTS1-receptor back to the cytosol.
  Platta, H.W., Grunau, S., Rosenkranz, K., Girzalsky, W. & Erdmann, R.
  Nat. Cell Biol. 7, 817-822 (2005)

2004

• Ubiquitination of the peroxisomal import receptor Pex5p.
  Platta, H.W., Girzalsky, W. & Erdmann, R.
  Biochem. J. 384, 37-45 (2004)

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