Autoantibody Project Biochemistry I - Receptor Biochemistry

Autoantibodies against Glutamate Receptors

Some types of brain inflammation occurring in humans are autoimmune diseases associated with antibodies against glutamate receptors. Recently the first case of such an autoimmune brain inflammation in an animal was reported, namely in the famous polar bear Knut. We are working on the characterisation of autoantibodies occurring in autoimmune brain inflammations as well as on the question whether autoantibodies against glutamate receptors play a role in other diseases of the nervous system as well.

Project-Related Publications

S. Arinrad, J.B.H. Wilke, A. Seelbach, J. Doeren, M. Hindermann, U.J. Butt, A.A. Steixner-Kumar, L. Spieth, A. Ronnenberg, H. Pan, S.A. Berghoff, M. Hollmann, F. Lühder, K.-A. Nave, K. Bechter, and H. Ehrenreich (2022).
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: A mild encephalitis model with neuropsychiatric relevance.
Molecular Psychiatry 27: 4974-4983.
doi: 10.1038/s41380-021-01392-8
Abstract
J.B.H. Wilke, M. Hindermann, S. Berghoff, S. Zihsler, S. Arinrad, A. Ronnenberg, N. Barnkothe, A.A. Steixner-Kumar, S. Röglin, W. Stöcker, M. Hollmann, K.-A. Nave, F. Lühder and H. Ehrenreich (2021).
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
Molecular Psychiatry 26: 7746-7759.
doi: 10.1038/s41380-021-01238-3
Abstract
H. Pan, A.A. Steixner-Kumar, A. Seelbach, N. Deutsch, A. Ronnenberg, D. Tapken, N. von Ahsen, M. Mitjans, H. Worthmann, R. Trippe, C. Klein-Schmidt, N. Schopf, K. Rentzsch, M. Begemann, J. Wienands, W. Stöcker, K. Weissenborn, M. Hollmann, K.-A. Nave, F. Lühder, and H. Ehrenreich (2021).
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.
Molecular Psychiatry 26: 2471-2482
doi: 10.1038/s41380-020-0672-1
Abstract
H. Ehrenreich, H. Pan, and M. Hollmann (2019).
Active immunization, autoimmunity and encephalitis: The missing links.
Letter to Science Translational Medicine. 11(500)
https://stm.sciencemag.org/content/11/500/eaaw0044/tab-e-letters
J.B.H. Wilke, H. Ehrenreich, and M. Hollmann (2019).
Autoantibodies against NMDA receptors – Janus-faced molecules?
Neuroforum 25(2).
doi: 10.1515/nf-2018-0025
Abstract
H. Pan, B. Oliveira, G. Saher, E. Dere, D. Tapken, M. Mitjans, J. Seidel, J, Wesolowski, D. Wakhloo, C. Klein-Schmidt, A. Ronnenberg, K. Schwabe, R. Trippe, K. Mätz-Rensing, S. Berghoff, Y. Al-Krinawe, H. Martens, M. Begemann, W. Stöcker, F.-J. Kaup, R. Mischke, S. Boretius, K.-A. Nave, J.K. Krauss, M. Hollmann, F. Lühder, and H. Ehrenreich (2019).
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
Molecular Psychiatry 24: 1489-1501.
doi: 10.1038/s41380-017-0011-3
Abstract
E. Castillo-Gómez, B. Oliveira, D. Tapken, S. Bertrand, C. Klein-Schmidt, H. Pan, P. Zafeiriou, J. Steiner, B. Jurek, R. Trippe, H. Prüss, W.-H. Zimmermann, D. Bertrand, H. Ehrenreich, and M. Hollmann (2017).
All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class.
Molecular Psychiatry 22: 1776-1784.
doi: 10.1038/mp.2016.125
Abstract Press Release
J. Trippe, K. Steinke, A. Orth, P.M. Faustmann, M. Hollmann, and C.G. Haase (2014).
Autoantibodies to glutamate receptor antigens in multiple sclerosis and Rasmussen's encephalitis.
Neuroimmunomodulation 21: 189-194.
doi: 10.1159/0003565197
Abstract

Project-Related Doctoral Theses

Jürgen Trippe
Investigations on the autoimmunity against ionotropic glutamate receptors in multiple sclerosis and Rasmussen's encephalitis patients
2014
Download thesis as pdf (4,9 MB)

Project-Related Master Theses

Katja Steinke
Analysis of autoimmunity against glutamate receptors in multiple sclerosis patients
03.03.2008 to 02.09.2008
Angela Orth
Analysis of autoimmunity against ionotropic glutamate receptors in multiple sclerosis and Rasmussen's encephalitis patients
01.03.2007 to 31.08.2007

Biochemistry I - Receptor biochemistry

Faculty of Chemistry and Biochemistry

Autoantibodies against Glutamate Receptors

Project-Related Publications

Project-Related Doctoral Theses

Project-Related Master Theses

Scientists Involved