Lehrstuhl fÜR TIERPHYSIOLOGIE

Beruflicher Werdegang

1983	Bachelor of Science im Fach Chemie, Tongji-Universität  Shanghai
1989	Diplom im Fach Chemie, Ruhr-Universität Bochum
1992	Promotion im Fach Biochemie, Ruhr-Universität Bochum
1993-1995	Postdoctor - Baylor College of Medicine, Houston, USA
1997	Gastwissenschaftler in Cold Spring Harbor Laboratory, New York, USA
1996-1998	Wissenschaftlicher Mitarbeiter, Leiter eines molekularbiologischen Labors im Institut für neurale Signalverarbeitung am ZMNH, Universität Hamburg
1998 -jetzt	Wissenschaftlicher Mitarbeiter, Leiter eines molekularbiologischen Labors im Lehrstuhl für Tierphysiologie der Fakultät für Biologie und Biotechnologie, Ruhr-Universität Bochum

Publikationen

O.Pongs, J.Lindemeier, X.R.Zhu, T.Theil, D.Engelkamp, I.Krah-Jentgens, H.Lambrecht, K.Koch, J.Schwemer, R.Rivosecchi, A.Mallart, J.Galceran, I.Canal, J.Barbas and A.Ferrus (1993). Frequenin-A Novel Calcium Binding Protein that Modulates Synaptic Efficacy in the Drosophila Nervous System. Neuron 11: 15-28. (Abstract online)

X.R.Zhu, F.Tejedor, A.Ackermann, A.Baumann, M.Heisenberg, and O.Pongs. (1994) minibrain- A Gene Encoding a Novel protein Kinase Family which Influences Develoment of Nervous System in Drosophila. The 1994 Meeting on Neurobiology of Drosphila, Cold Spring harbor Laboratory, New York.

F.Tejedor, X.R.Zhu, E.Kaltenbach, A.Ackermann, A.Baumann, I.Canal, M.Heisenberg, K.Fischbach and O.Pongs. (1995) minibrain: A New Protein Kinase Family Involved in Postembryonic Neurogenesis in Drosophila. Neuron 14: 287-301. (Abstract online)

X.R.Zhu, K.H.Wu and R.L.Davis. (1995) Volado- A Gene Encoding a Novel a-Subunit of Integrin which Influences Fly Learning. The 36^th annual Drosophila Research Conference, Atlanta, (1995), Genetics Society of America 14: 347.

X.R.Zhu, K.H.Wu and R.L.Davis. (1995) Volado-A Gene Encoding a Novel alpha-Subunit of Integrin that Influences Learning. The 1995 Meeting on Neurobiology of Drosphila, Cold Spring Harbor Laboratory, New York.

M.S.Grotewiel, C.D.O.Beck, K.H.Wu, X.R.Zhu and R.L.Davis. (1998) Integrin-Mediated Short-Term Memory in Drosophila. Nature 391: 455-460. (Abstract)

X.R.Zhu, R.Netzer, K.Bölke, M.Schweizer, J.Rettig, S.Fehr and O.Pongs. (1998) Kv6.2, a new potassium channel a-subunit with specific regulatory properties for the Kv2.1 channel. Eur. J. Neurosci. 10: 113.

X.R.Zhu, R.Netzer, K.Bölke Q. Liu and O.Pongs. (1999) Structural and Functional Characterization of Kv6.2, a New g-Subunit of Voltage-Gated Potassium Channel. Receptors Channels 6: 337-350. (Abstract online)

X.R. Zhu, A. Wulf, M. Schwarz, D. Isbrandt and O. Pongs. (1999) Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K⁺ current. Receptors Channels 6: 387-400. (Abstract online)

D. Isbrandt, T. Leicher, R. Waldschütz, X.R. Zhu, U. Luhmann, U. Michel, K. Sauter and O. Pongs. (2000) Gene Structures and Expression Profiles of Three Human KCND (Kv4) Potassium Channels Mediating A-Type Currents I_TO and I_SA. Genomics 64: 144-154. (Abstract online)

Stichel, C.C., M. Augustin, K. Kühn, X.-R. Zhu, P. Engels, C. Ullmer, H. Lübbert (2000) Parkin expression in the adult mouse brain. Eur. J. Neurosci. 12: 4181-4195.  (Abstract online)

Sitek, B., Poschmann, G., Schmidtke, K., Ullmer, C., Maskri, L., Andriske, M., Stichel-Gunkel, C.C., Zhu, X.R., and Lübbert, H. (2003) Expression of MUPP1 protein in mouse brain. Brain Res. 970(1-2): 178-87. (Abstract online)

Kühn, K., Zhu, X.R., Lübbert, H., Stichel, C.C. (2004) Parkin expression in the developing mouse. Dev. Brain Res. 149 (2),131-142. (Abstract online)

Maskri L., Zhu X.R., Fritzen S., Kühn K., Ullmer C., Engels P., Andriske M., Stichel C.C., Lübbert H. (2004) Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice. Neurodegenerative dis. 1 (6), 255-65. (Article Full Text PDF, 1510 kb)

Stichel C.C., Schönebeck B., Foguet M., Siebertz B., Bader V., Zhu X.R., Lübbert H. (2005) Sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson`s disease. Eur. J. Neurosci. 21 (2), 301-316. (Abstract online)

Bader V., Zhu X.R., Lübbert H., Stichel C.C. (2005) Expression of DJ-1 in the adult mouse brain. Brain Res. 1041 (1), 102-11. (Abstract online)

Schönebeck B., Bader V., Zhu X.R., Schmitz B., Lübbert H., Stichel C.C. (2005) Sgk1, a cell survival response, in neurodegenerative diseases. Mol. Cell. Neurosci. 30 (2), 249-64. (Abstract online)

Leichsenring, A., Linnartz B., Zhu X.R., Lübbert H., Stichel C.C. (2006) Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. Brain Res. 1096 (1), 180-195. (Abstract online)

Wendt, W., Zhu X.R., Lübbert H., Stichel C.C. (2007) Differential expression of cathepsin X in aging and pathological central nervous system of mice. Exp Neurol. 204 (2), 525-40. (Abstract online)

Stichel, C.C., Zhu X.R., Bader V., Linnartz B., Schmidt B., Lübbert H. (2007) Mono- and double-mutant mouse models of Parkinson`s disease display severe mitochondrial damage. Hum Mol Genetics, 16 (20), 3377-93. (Article Full Text PDF, 1660 kb)

Zhu X.R., Maskri L., Herold C., Bader V., Stichel C.C., Güntürkün O., Lübbert H. (2007) Non-motor behavioral impairments in parkin-deficient mice. Eur. J. Neurosci. 26 (7), 1902-11. (Article Full Text PDF, 425 kb)

Estévez M.A., Henderson J.A., Ahn D., Zhu X.R., Poschmann G., Lübbert H., Marx R., Baraban J.M. (2008) The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1. Eur. J. Neurochem. 106 (3), 1287-97. (Article Full Text PDF, 602 kb)

Sergeeva, O.A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S.R., Goerg, B., Haas, H.L., Zhu, X.R., Lübbert, H., Gisselmann, G., Hatt, H. (2010) Fragrant dioxane derivatives identify {beta}1 subunit-containing GABAA receptors. J. Biol. Chem. 285(31), 23985-93. (Abstract online) (Article Full Text PDF, 2481 kb)

Mendritzki, S., Schmidt, S., Sczepan, T., Zhu, X.R., Segelcke, D. and Lübbert, H.(2010) Spinal cord pathology in alpha-synuclein transgenic mice. Parkinson's Disease (Abstract online) (Article Full Text PDF, 12171 kb)

Yanovsky, Y., Schubring, S., Fleischer, W., Gisselmann, G., Zhu, X.R., Lübbert, H., Hatt, H., Rudolph, U., Haas, H.L., Sergeeva, O.A. (2011) GABA(A) receptors involved in sleep and anaesthesia: beta1- versus beta3-containing assemblies. Pflugers Arch 463(1), 187-199. (Abstract online) (Article Full Text PDF, 780 kb)

Tanabe, Y., Fujita, E., Hayashi, Y., Zhu, X.R., Lübbert, H., Mezaki, Y., Senoo, H., Momoi, T. (2013) Synaptic adhesion molecules in Cadm family at the neuromuscular junction. Cell Biol Int 37(7), 731-6. (Abstract online)

Schmitz, B., Ullmer, C., Segelcke, D., Gwarek, M., Zhu, X.R., Lübbert, H. (2015) BF-1 - A novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 751C, 73-80. (Abstract online)

Hunfeld, A., Segelcke, D., Bäcker, I., Mecheri, B., Hemmer, K., Dlugosch, E., Andriske, M., Paris, F., Zhu, X.R. & Lübbert, H. (2015) Hypoxia facilitates neurogenic dural plasma protein extravasation in mice: a novel animal model for migraine pathophysiology. Sci Rep 5, 178545. (Abstract online) (Article Full Text PDF, 1686 kb)