Publication of the Year 2021
L. D. Stanchev, J. Rizzo, R. Peschel, L.A. Pazurek, L. Bredegaard, S. Veit, S. Laerbusch, M.L. Rodrigues, R.L. López-Marqués and T. Günther Pomorski (2021).
P-type ATPase Apt1 of the fungal pathogen Cryptococcus neoformans is a lipid flippase of broad substrate specificity.
Journal of Fungi 7(10): 843
doi: 10.3390/jof7100843
Abstract
This work identifies the P-Type ATPase Apt1 of the fungal pathogen Cryptococcus neoformans in complex with Cdc50p as lipid flippase with a broad substrate specificity. This finding implies that transbilayer lipid transport in C. neoformans is finely regulated to promote fungal virulence. The established heterologous expression system for Apt1pCdc50p may prove useful for further detailed biochemical analysis aimed at identifying novel antagonists of this transporter class that might help in the treatment of cryptococcal meningitis and related infections in humans. The paper was selected as Editors Choice Article.
