DFG-Forschergruppe 630

Biologische Funktion von Organometallverbindungen
Biological function of organometallic compounds

This page lists *only* collaborative work that resulted in joint publications of at least two grops within FOR 630.
For a complete list of all publications from the groups during funding of FOR630, please see the individual homepage of the group of interest!"

Ergebnisse 2013

  • R. Rubbiani, E. Schuh, A. Meyer, J. Lemke, J. Wimberg, N. Metzler-Nolte, A. Meyer, F. Mohr, I. Ott
    TrxR inhibition and antiproliferative activities of structurally diverse gold N-heterocyclic carbene complexes
    Med. Chem. Commun. 4 (2013) 942-948.
  • L. Oehninger, L. N. Küster, C. Schmidt, A. Muñoz-Castro, A. Prokop, I. Ott
    A Chemical–Biological Evaluation of Rhodium(I) N-Heterocyclic Carbene Complexes as Prospective Anticancer Drugs
    Chem. Eur. J. 2013.
  • P. V. Simpson, C. Schmidt, I. Ott, H. Bruhn, U. Schatzschneider
    Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N-Heterocyclic Carbene Complexes Bearing Charged Substituents
    Eur. J. Inorg. Chem. (2013) 5547–5554.
  • M. Wenzel, M. Patra, Ch. H. R. Senges, I. Ott, J. J. Stepanek, A. Pinto, P. Prochnow, C. Vuong, S. Langklotz, N. Metzler-Nolte, J. E. Bandow
    Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics
    ACS Chem. Biol. 8 (7) (2013) 1442–1450.
  • K. Navakoski de Oliveira, V. Andermark, S. von Grafenstein, L. A. Onambele, G. Dahl, R. Rubbiani, G. Wolber, Ch. Gabbiani, L. Messori, A. Prokop, I. Ott
    Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins
    ChemMedChem 8 (2) (2013) 256–264.
  • H. Pfeiffer, M. Dragoun, A. Prokop, U.Schatzschneider
    Biological Activity of Molybdenum(II) Allyl Dicarbonyl Complexes with N–N Coligands of Variable Aromatic Surface Area on Adherent and Non-adherent Human Cancer Cells
    Z. Anorg. Allg. Chem. (2013) 1568–1576.
  • Ch. Hirschhäuser ,J. Velcicky, D. Schlawe, E. Hessler, A. Majdalani, J.-M. Neudörfl, A. Prokop, T. Wieder, H.-G. Schmalz
    Nucleoside Analogues with a 1,3-Diene-Fe(CO)3 Substructure: Stereoselective Synthesis, Configurational Assignment, and Apoptosis-Inducing Activity
    Chem. Eur. J. 19 (2013) 13017–1302.
  • L. Oehninger, M. Stefanopoulou, H. Alborzinia, J. Schur, S. Ludewig, K. Namikawa, A. Muñoz-Castro, R. W. Köster, K. Baumann, S. Wölfl, W. S. Sheldrick, I. Ott
    Evaluation of Arene Ruthenium(II) N-heterocyclic Carbene Complexes as Organometallics Interacting with Thiol and Selenol Containing Biomolecules
    Dalton Trans. 42 (2013) 1657-1666.

Ergebnisse 2012

  • A. Meyer, C. P. Bagowski, M. Kokoschka, M. Stefanopoulou, H. Alborzinia, S. Can, D. H. Vlecken, W. S. Sheldrick, S. Wölfl, I. Ott
    On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes
    Angew. Chem. Int. Ed. 51 (2012) 8895-8899.
  • W. Hu, K. Splith, I. Neundorf, K. Merz, U. Schatzschneider
    Influence of the metal center and linker on the intracellular distribution and biological activity of organometal-peptide conjugates
    J. Biol. Inorg. Chem. 17 (2012) 175-185.
  • A. Gross, N. Hüsken, J. Schur, L. Raszeja, I. Ott, N. Metzler-Nolte
    A ruthenocene-PNA bioconjugate - synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake
    Bioconjugate Chem. 23 (2012) 1764-1774.
  • S. D. Köster, H. Alborzinia, S. Can, I. Kitanovic, S. Wölfl, R. Rubbiani, I. Ott, P. Riesterer, A. Prokop, K. Merz, N. Metzler-Nolte
    A spontaneous gold(I)-azide alkyne cycloaddition reaction yields gold-peptide bioconjugates which overcome cisplatin resistance in a p53-mutant cancer cell line
    Chem. Sci. 3 (2012) 2062-2072.
  • M. A. Nazif, R. Rubbiani, H. Alborzinia, I. Kitanovic, S. Wölfl, I. Ott, W. S. Sheldrick
    Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands
    Dalton Trans. 41 (2012) 5587-5598.
  • M. Krüger, M. Huang, H. Becker-Roß, S. Florek, I. Ott, R. Gust
    Quantification of the fluorine containing drug 5-fluorouracil in cancer cells by GaF molecular absorption via high-resolution continuum source molecular absorption spectrometry
    Spectrochim. Acta, part B 69 (2012) 50-55.
  • Y. Geldmacher, K. Splith, I. Kitanovic, H. Alborzinia, S. Can, R. Rubbiani, M. A. Nazif, P. Wefelmeyer, A. Prokop, I. Ott, S. Wölfl, I. Neundorf, W. S. Sheldrick
    Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts
    J. Biol. Inorg. Chem. 17 (2012) 631-636.
  • C. Kasper, H. Alborzinia, S. Can, I. Kitanovic, A. Meyer, Y. Geldmacher, M. Oleszak, I. Ott, S. Wölfl, W. S. Sheldrick
    Synthesis and cellular impact of diene-ruthenium(II) complexes: A new class of organoruthenium anticancer agents
    J. Inorg. Biochem. 106 (2012) 126-133.
  • J. Hoyer, U. Schatzschneider, M. Schulz-Siegmund, I. Neundorf
    Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery
    Beilstein J. Org. Chem. 8 (2012) 1788-1797.
  • J. Hoyer, A. Hunold, H.-G. Schmalz, I. Neundorf
    A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?
    Dalton Trans. 41 (2012) 6396-6398.
  • N. Sitnikov, J. Velder, L. Abodo, N. Cuvelier, J. Neudörfl, A. Prokop, G. Krause, A. Y. Fedorov, H.-G. Schmalz
    Total Synthesis of Indole-derived Allocolchicine Analogs Exhibiting Strong Apoptosis-inducing Activity
    Chem. Eur. J. 18 (2012) 12096-12102.
  • A. O. Termath, S. Ritter, M. König, D. P. Kranz, J.-M. Neudörfl, A. Prokop, H.-G. Schmalz
    Synthesis of Oxa-B-Ring Analogs of Colchicine through Rh Catalyzed Intramolecular [5+2] Cycloaddition
    Eur. J. Org. Chem. (2012) 4501-4507.

Ergebnisse 2011

  • S. Romanski, B. Kraus, U. Schatzschneider, J.-M. Neudörfl, S. Amslinger, H.-G. Schmalz
    Acyloxybutadiene-Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)
    Angew. Chem. 123 (2011) 2440-2444.
    Angew. Chem. Int. Ed. 50 (2011) 2392-2396.
  • N. Kausch-Busies, J.-M. Neudörfl, P. Wefelmeier, A. Prokop, H. Kühn, H.-G. Schmalz
    Stereoselective Synthesis and Biological Evaluation of Ferrocene-Containing, HETE-Analogs
    Eur. J. Org. Chem. 24 (2011) 4634-4644.
  • N. Kausch-Busies, B. Kater, J. M. Neudörfl, A. Prokop, H.-G. Schmalz
    Synthesis and First Biological Evaluation of an Iron-Containing HETE-Analogue
    Eur. J. Org. Chem. (2011) 1133-1139.
  • B. Kater, A. Hunold, L. Kater, B. Bonitzki, P. Jesse, A. Prokop, H.-G. Schmalz
    Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative
    J. Cancer Res. Clin. Oncol. 137 (2011) 639-649.
  • R. Rubbiani, S. Can, I. Kitanovic, H. Alborzinia, M. Stefanopoulou, M. Kokoschka, S. Mönchgesang, W. S. Sheldrick, S. Wölfl, I. Ott
    Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type
    J. Med. Chem. 54 (2011) 8646-8657.
  • G. Gasser, S. Neumann, I. Ott, M. Seitz, R. Heumann, N. Metzler-Nolte
    Preparation and biological evaluation of di-hetero organometallic-containing PNA bioconjugates
    Eur. J. Inorg. Chem. (2011) 5471-5478.
  • L. Oehninger, H. Alborzinia, S. Ludewig, K. Baumann, S. Wölfl, I. Ott
    From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects ?
    ChemMedChem 6 (2011) 2142-2145.
  • F. Hackenberg, L. Oehninger, H. Alborzinia, S. Can, I. Kitanovic, Y. Geldmacher, M. Kokoschka, S. Wölfl, I. Ott, W. S. Sheldrick
    Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells
    J. Inorg. Biochem. 105 (2011) 991-999.
  • R. Bieda, I. Kitanovic, H. Alborzinia, A. Meyer, I. Ott, S. Wölfl, W. S. Sheldrick
    Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes
    Biometals 24 (2011) 645-661.
  • Y. Geldmacher, R. Rubbiani, P. Wefelmeier, A. Prokop, I. Ott, W. S. Sheldrick
    Synthesis and DNA-binding properties of apoptosis-inducing cytotoxic half-sandwich rhodium(III) complexes with methyl-substituted polypyridyl ligands
    J. Organomet. Chem. 696 (2011) 1023-1031.
  • Y. Geldmacher, I. Kitanovic, H. Alborzinia, K. Bergerhoff, R. Rubbiani, P. Wefelmeier, A. Prokop, R. Gust, I. Ott, S. Wölfl, W. S. Sheldrick
    Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl-substituted Phenanthroline Ligands
    ChemMedChem 6 (2011) 429-439.
  • A. Hille, T. Wolf, P. Schumacher, I. Ott, R. Gust, B. Kircher
    Effects of metal salophene and saldach complexes on lymphoma and leukemia cells
    Arch. Pharm. Chem. Life Sci. 11 (2011) 217-223.
  • S. Y. Lee, A. Hille, I. Kitanovic, P. Jesse, G. Henze, S. Wölfl, R. Gust, A. Prokop
    Fe (III) (salophene) CI, a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells
    Leuk. Res. (2011) 387-393.

Ergebnisse 2010

  • J. C. Frankea, M. Plötza, A. Prokop, C. C. Geilena, H.-G. Schmalz, J. Eberle
    New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue
    Biochemical Pharmacology 79 (2010) 575-586.
  • N. Nicolaus, J. Zapke, P. Riesterer, J.-M. Neudörfl, A. Prokop, H. Oschkinat, H.-G. Schmalz
    Azides Derived from Colchicine and their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug
    ChemMedChem 5 (2010) 661-665.
  • K. Splith, I. Neundorf, W. Hu, H.W. Peindy N'Dongo, V. Vasylyeva, K. Merz, U. Schatzschneider
    Influence of the metal complex-to-peptide linker on the synthesis and properties of bioactive CpMn(CO)3 peptide conjugates
    Dalton Trans. 39 (2010) 2536-2545.
  • K. Meister, J. Niesel, U. Schatzschneider, D. Schmidt, N. Metzler-Nolte, M. Havenith-Newen
    Markierungsfreie Visualisierung von löslichen Metallcarbonylkomplexen in lebenden Zellen mithilfe von Raman-Mikrospektroskopie
    Angew. Chem. 122 (2010) 3382-3384.
  • S. P. Mulcahy, K. Gründler, C. Frias, L. Wagner, A. Prokop, E. Meggers
    Discovery of a Strongly Apoptotic Ruthenium Complex through Combinatorial Coordination Chemistry
    Dalton Trans. 39 (2010) 8177-8182.
  • X. He, L. Gogn, K. Kräling, K. Gründler, C. Frias, R. D. Webster, E. Meggers, A. Prokop, H. Xia
    Unusual Allene Osmacycle with Apoptotic Properties
    Chem. Bio. Chem. 11 (2010) 1607-1613.
  • R. Rubbiani, I. Kitanovic, H. Alborzinia, S. Can, A. Kitanovic, L. A. Onambele, M. Stefanopoulou, Y. Geldmacher, W. S. Sheldrick, G. Wolber, A. Prokop,S. Wölfl,I. Ott
    Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties
    J. Med. Chem. 53 (2010) 8608-8618.
  • G. Rubner, K. Bensdorf, A. Wellner, S. Bergemann, I. Ott, R. Gust
    [Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents
    Eur. J. Med. Chem. 45 (2010) 5157-5163.
  • G. Rubner, K. Bensdorf, A. Wellner, B. Kirchner, S. Bergemann, I. Ott, R. Gust
    Synthesis and biological activities of transition metal complexes based on acetylsalicylic acid as neo-anticancer agents
    J. Med. Chem. 53 (2010) 6889-6898.
  • R. Bieda, M. Dobroschke, A. Triller, I .Ott, M. Spehr, R. Gust, A. Prokop, W. S. Sheldrick
    Cell selective, apoptosis-inducing rhodium(III) crown thiaether complexes
    ChemMedChem 5 (2010) 1123-1133.
  • K. Splith, W. Hu, U. Schatzschneider, R. Gust, I. Ott, L. A. Onambele, A. Prokop, I. Neundorf
    Protease-activatable organometal-peptide bioconjugates with enhanced cytotoxicity on cancer cells
    Bioconjug. Chem. 21 (2010) 1288-1296.
  • K. Butsch, R. Gust, A. Klein, I. Ott, M. Romanski
    Tuning the electronic properties of dppz-ligands and their palladium(II) complexes
    Dalton Trans. 39 (2010) 4331-4340.
  • I. Ott, K. Kowalski, R. Gust, J. Maurer, P. Mücke, R. F. Winter
    Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene / ruthenium organometallic species
    Bioorg. Med. Chem. Lett. 20 (2010) 866-869.
  • S. Y. Lee, A. Hille, C. Frias, B. Kater, B. Bonitzki, S. Wölfl, H. Scheffler, A. Prokop, R. Gust.
    [NiII(3-OMe-salophene)]: a potent agent with antitumor activity
    J Med Chem. (2010) 6064-6070.

Ergebnisse 2009

  • N. Nicolaus, S. Strauss, J. Neudörfl, A. Prokop, H.-G. Schmalz
    A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity
    Org. Lett. 11 (2009) 341-344.
  • E. Meggers, G. E. Atilla-Gokcumen, K. Gründler, C. Frias, A. Prokop
    Inert Ruthenium Half-Sandwich Complexes with Anticancer Activity
    Dalton Trans. (2009) 10882-10888.
  • M. Patra, G. Gasser, A. Pinto, K. Merz, I. Ott, E. J. Bandow, N. Metzler-Nolte
    Synthesis and biological evaluation of chromium bioorganometallics based on the antibotic platensimycin lead structure
    ChemMedChem 4 (2009) 1930-1938.
  • A. Nazif, J. A. Bangert, I. Ott, R. Gust, R. Stoll, W. S. Sheldrick
    Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA-binding
    J. Inorg. Biochem. 103 (2009) 1405-1414.
  • I. Neundorf, R. Rennert, J. Hoyer, F. Schramm, K. Löbner, I. Kitanovic, S. Wölfl
    Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity
    Pharmaceuticals 2 (2009) 49-65.
  • R. Bieda, I. Ott, R. Gust, W. S. Sheldrick
    Cytotoxic rhodium(III) polypyridyl complexes containing the tris(pyrazolyl)methane coligand: synthesis, DNA binding properties and structure-activity relationships
    Eur. J. Inorg. Chem. (2009) 3821-3831.
  • I. Ott, X. Qian, Y. Xu, D.H.W. Vlecken, I.J. Marques, D. Kubutat, J. Will, W. S. Sheldrick, P. Jesse, A. Prokop, C.P. Bagowski
    A Gold(I) Phosphine Complex Containing Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor
    J. Med. Chem. 53 (2009) 763-770.
  • C. Walther, I. Ott, R. Gust, I. Neundorf
    Specific labeling with potent radiolabels alters the uptake of cell-penetrating peptides
    Biopolymers 92 (2009) 445-451.
  • R. Bieda, I. Ott, M. Dobroschke, A. Prokop, R. Gust, W. S. Sheldrick
    Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS3
    J. Inorg. Biochem. 103 (2009) 698-708
  • M. Dobroschke, Y. Geldmacher, I. Ott, M. Harlos, L. Kater, L. Wagner, R. Gust, W. S. Sheldrick, A. Prokop
    Cytotoxic Rhodium(III) and Iridium(III) Polypyridyl Complexes: Structure-Activity Relationships, Antileukemic Activity and Apoptosis Induction
    ChemMedChem 4 (2009) 177-187.
  • F. Noor, R. Kinscherf, G.A. Bonaterra, S. Walczak, S. Wölfl, N. Metzler-Nolte
    Enhanced Cellular Uptake and Cytotoxicity Studies of Organometallic Bioconjugates of the NLS Peptide in Hep G2 Cells
    ChemBioChem 10 (2009) 493-502.
  • I. Ott, X. Qian, Y. Xu, D. Kubutat, J. Will, W. S. Sheldrick, P. Jesse, A. Prokop, C. Bagowski
    A gold(I) phosphine complex containing naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor
    J. Med. Chem. 52 (2009) 763-770.
  • A. Hunold, I. Neundorf, P. James, J. Neudörfl, H.-G. Schmalz
    Stereoselective Synthesis of new Ferrocene-derived Amino Acid Building Blocks
    Eur. J. Org. Chem. (2009) 4429-4440.
  • A. Hille, I. Ott, A. Kitanovic, I. Kitanovic, H. Alborzina, E. Lederer, S. Wölfl, N. Metzler-Nolte, S. Schäfer, W.S. Sheldrick, C. Bischof, U. Schatzschneider, R. Gust
    [N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties
    J. Biol. Inorg. Chem. 14, 711-725 (2009)
  • H. Pfeiffer, A. Rojas, J. Niesel, U. Schatzschneider
    Sonogashira and "Click" reactions in the N-terminal and side chain functionalization of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm = tris(pyrazolyl)methane)
    Dalton Trans. 4292-4298 (2009)
  • H.W. Peindy N'Dongo, I. Ott, R. Gust, U. Schatzschneider
    Microwave-assisted solid-phase synthesis, cellular uptake, and cytotoxicity studies of cymantrene-peptide bioconjugates
    J. Organomet. Chem. 694 (2009) 823-827
  • I. Ott, B. Kircher, C.P. Bagowski, D.H.W. Vlecken, E.B. Ott, J. Will, K. Bensdorf, W. S. Sheldrick, R. Gust
    Modulation of the Biological Properties of Aspirin by Bioorganometallic Derivatisation
    Angew. Chem. Int. Ed. 48 (2009) 1160-1163.
  • R. Rennert, I. Neundorf, A. G. Beck-Sickinger
    Synthesis and application of peptides as drug carriers.
    Methods Mol Biol. 535 (2009) 389-403.
  • K. Kölbel, C. Ihling, K. Bellmann-Sickert, I. Neundorf, A. G. Beck-Sickinger, A. Sinz, U. Kühn, E. Wahle.
    Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively.
    J Biol Chem. 284 (2009) 8274-8282.

Ergebnisse 2008

  • M. Schlenk, I. Ott, R. Gust
    Cobalt-Alkyne Complexes with Imidazoline Ligands as Estrogenic Carriers: Synthesis and Pharmacological Investigations
    J. Med. Chem. 51 (2008) 7318-7322.
  • M. A. Scharwitz, I. Ott, Y. Geldmacher, R. Gust, W. S. Sheldrick
    Cytotoxic half-sandwich rhodium(III) complexes: polypyridyl ligand influence on their DNA binding properties and cellular uptake
    J. Organomet. Chem. 693 (2008) 2299 - 2309.
  • M. A. Scharwitz, I. Ott, R. Gust, A. Kromm, W. S. Sheldrick
    Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichlorididoiridium(III) polypyridyl complexes
    J. Inorg. Biochem. 102 (2008) 1623 - 1630.
  • I. Ott, M. Scharwitz, H. Scheffler, W. S. Sheldrick, R. Gust
    Atomic absorption spectrometric determination of the iridium content of tumor cells exposed to an iridium metallodrug
    J. Pharm. Biomed. Anal. 47 (2008) 938 - 942.
  • I. Neundorf, J. Hoyer, K. Splith, R. Rennert, H.W. Peindy N'Dongo, U. Schatzschneider
    Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide
    Chem. Commun. (2008) 5604-5606
  • H.W. Peindy N'Dongo, I. Neundorf, K. Merz, U. Schatzschneider
    Synthesis, characterization, and X-ray crystallography of cymantrene keto carboxylic acids for IR labelling of bioactive peptides on a solid support
    J. Inorg. Biochem. 102 (2008) 2114-2119
  • M. Harlos, I. Ott, R. Gust, H. Alborzinia, S. Wölfl, A. Kromm, W. S. Sheldrick
    Synthesis, biological activity and structure activity relationships for potent cytotoxic rhodium (III) polypyridyl complexes
    J. Med. Chem. 51 (2008) 3924-3933
  • U. Schatzschneider, J. Niesel, I. Ott, R. Gust, H. Alborzinia, S. Wölfl
    Cellular Uptake, Cytotoxicity, and Metabolic Profiling of Ruthenium(II) Polypyridyl Complexes [Ru(bpy)2(N-N)]Cl2 with N-N = bpy, phen, dpq, dppz, and dppn
    ChemMedChem 3 (2008) 1104-1109
  • S. I. Kirin, I. Ott, R. Gust, W. Mier, T. Weyhermüller, N. Metzler-Nolte
    Cellular uptake quantification of metallated peptide and peptide nucleic acid bioconjugates by atomic absorption spectroscopy
    Angew. Chem. Int. Ed. (2008), 47, 955-959; Angew. Chem. (2008), 120, 969-973
  • C. D.Sergeant, I. Ott, A. Sniady, S. Meneni, R. Gust, A. L. Rheingold, R. Dembinski
    Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines
    Org. Biomol. Chem. 6 (2008) 73-80
  • I. Ott, B. Kircher, R Dembinski., R. Gust
    Alkyne hexacarbonyl dicobalt complexes in medicinal chemistry and drug development
    Expert Opin. Therap. Patents 18 (2008) 327-337
  • T. Kapp, M. Krüger, I. Ott, S. Steiner, P. Schumacher, D. Nachbaur, G. Gastl, R. Gust, B. Kircher
    Biological effect of mono- and dinuclear alkylamine platinum(II) compounds on human lymphoma cells
    J. Inorg. Biochem. 102 (2008) 713-720
  • R. Rennert, I. Neundorf, H. Jahnke, P. Suchowerskyj, P. Dournaud, A. Robitzki, A. G. Beck-Sickinger
    Generation of carrier peptides for the delivery of nucleic acid drugs in primary cells
    ChemMedChem 3 (2008) 241-253
  • J. Niesel, A. Pinto, H.W. Peindy N'Dongo, K. Merz, I. Ott, R. Gust, U. Schatzschneider
    Photoinduced CO release, cellular uptake, and cytotoxicity of a tris(pyrazolyl)methane manganese tricarbonyl complex
    Chem. Commun. (2008) 1798-1800

Ergebnisse 2007

  • I. Ott, H. Scheffler, R. Gust
    Development of a method for the quantification of the molar gold concentration in tumor cells exposed to gold containing drugs
    ChemMedChem 2 (2007) 702-707
  • R. Gust, Ingo Ott
    Non-platinum metal complexes as anti-cancer drugs
    Arch. Pharm. 340 (2007) 117-126
  • R. Gust, Ingo Ott
    Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment
    Anti-Cancer Agents in Medicinal Chemistry 7 (2007) 95-110
  • S. Schäfer, I. Ott, R. Gust, W. S. Sheldrick
    Influence of the polypyridyl (pp) ligand size on the DNA binding properties, cytotoxicity and cellular uptake of organoruthenium(II) complexes of the type [(η6-C6Me6)Ru(L)(pp)]n+ [L = Cl, n=1; L = (NH2)2CS, n=2]
    Eur. J. Inorg. Chem. (2007) 3034-3046

Ergebnisse 2006

  • I. Ott, A. Abraham, P. Schumacher, H. Shorafa, G. Gastl, R. Gust, B. Kircher
    Synergistic and additive antiproliferative effects on human leukemia cell lines induced by combining acetylenehexacarbonyldicobalt complexes with the tyrosine kinase inhibitor imatinib
    J. Inorg. Biochem. 100 (2006) 1903-19063
  • I. Ott, R. Gust
    Medizinische Chemie der Platinkomplexe. (written in German)
    Pharm. Unserer Zeit 35 (2006) 124-133
  • U. Schatzschneider, N. Metzler-Nolte
    New emerging principles in medicinal organometallic chemistry
    Angew. Chem. 118 (2006) 1534-1537
  • S.I. Kirin, U. Schatzschneider, X. de Hatten, T. Weyhermüller, N. Metzler-Nolte
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