Lehrstuhl für Zellmorphologie und Molekulare Neurobiologie - Projekt

1981-1982 1st Post-doc, MRC, Dept. of Zoology, UCL London, UK (Prof. Raff)
1982-1984 2nd Post-doc, Neurobiologie, Universität Heidelberg (Prof. Schachner)
1985-1999 Principle Investigator (PI, DFG, SFB 317), Neurobiologie, Uni. Heidelberg
1991 Privatdozent, Gruppenleiter, Neurobiologie, Univ. Heidelberg (Prof. Huttner)
1993-1998 Schilling-Stiftungs-Professur für Neurowissenschaften (C3 auf Zeit, 5 Jahre)
1998 Professeur de Neurobiologie 2ième classe (ULP Straßburg, Frankreich)
1998 Direktor der CNRS Abteilung LNDR UPR 1352, Straßburg
1999 Professeur de Neurobiologie 1ière classe, ULP Straßburg, Frankreich
2000-jetzt Professor (C4) and Direktor des Lehrstuhls für Zellmorphologie und Molekulare Neurobiologie der Ruhr-Universität, Bochum, Germany.

Akademische Funktionen (Auswahl)

1996-aktuell Editorial Board der Zeitschrift GLIA
1997-2000 Sprecher der Université Louis Pasteur (Straßburg) im neurowissenschaftlichen Netzwerk des oberen Rheintals (NEUREX)
2003-2012 Editorial Board der Zeitschrift Neuron Glia Biology
2004-2006 Stellvertretendes Mitglied im Senat der Ruhr-Universität
2004-2006 Studiendekan der Fakultät für Biologie und Biotechnologie der RUB
2005-2012 Board of Directors der IGSN, Ruhr-Universität
2012-aktuell Stellvertretendes Mitglied im Board of Directors der IGSN
2008-aktuell Editorial Board and Lead Editor der Zeitschrift Stem Cells
2008-aktuell Sprecher der Ruhr-Universität im Stammzellnetzwerk NRW
2008-2012 Prodekan der Fakultät für Biologie und Biotechnologie der RUB
2010-aktuell Principal Investigator und Mitglied im Direktorium des Research Department for Neuroscience (RDN) der Ruhr-Universität
2012-aktuell Dekan der Fakultät für Biologie und Biotechnologie der RUB
2013-aktuell Berufenes Mitglied der Faculty of 1000

Wissenschaftliche Schwerpunkte

Das Forschungsgebiet ist die zelluläre und molekulare Neurobiologie, mit den Schwerpunkten Entwicklung, Plastizität und Regeneration des ZNS. Themen sind die strukturelle und funktionelle Charakterisierung von Zelladhäsionsmolekülen, von Komponenten der Extrazellulärmatrix und komplexer Glykane in neuralen Stammzellen, bei Neuron-Glia Wechselwirkungen, bei Axonwachstum und –lenkung, bei Synaptogenese und synaptischer Plastizität sowie bei der Hemmung der Regeneration des ZNS. In jüngerer Zeit stehen in diesem Rahmen die Signaltransduktion durch Tyrosinphosphatasen und kleine GTPasen der Rho-Familie und deren Regulationsfaktoren im Mittelpunkt. Methodisch verwendet die Arbeitsgruppe ein weites Repertoire biochemischer, zell- und molekularbiologischer, immunologischer und morphologischer Ansätze, unter Einschluss genetisch modifizierter Mausmodelle.

Publications

2013

Brösicke N, van Landeghem F, Scheffler B, Faissner A (2013) Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels. Cell Tissue Res, in press.
Tsai T, Klausmeyer A, Conrad R, Gottschling C, Leo M, Faissner A, Wiese S (2013) 7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways. Mol Cell Neurosci 56C:18-28.
Pacharra S, Hanisch FG, Muhlenhoff M, Faissner A, Rauch U, Breloy I (2013) The Lecticans of Mammalian Brain Perineural Net Are O-Mannosylated. Journal of proteome research 12:1764-1771.
Karus M, Hennen E, Safina D, Klausmeyer A, Wiese S, Faissner A (2013) Differential Expression of Micro-Heterogeneous LewisX-Type Glycans in the Stem Cell Compartment of the Developing Mouse Spinal Cord. Neurochemical research 38:1285-1294.
Hennen E, Safina D, Haussmann U, Worsdorfer P, Edenhofer F, Poetsch A, Faissner A (2013) A LewisX-glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice. J Biol Chem. 288:16538-16545.
Geissler M, Gottschling C, Aguado A, Rauch U, Wetzel CH, Hatt H, Faissner A (2013) Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci 33:7742-7755.

2012

Wiese S, Karus M, Faissner A (2012) Astrocytes as a source for extracellular matrix molecules and cytokines. Frontiers in pharmacology 3:120.
Tsai T, Karus M, Faissner A, Wiese S (2012) Wie aus neuralen Stammzellen gezielt Nervenzellen werden. BIOforum 2/2012:2-4.
Theocharidis U, Faissner A (2012) Analysis of alternatively spliced domains in multimodular gene products – the extracellular matix glycoprotein tenascin C. In: Polymerase Chain Reaction (Hernandez-Rodriguez P, ed): InTech, Chapter 23, 487-500.
Roll L, Mittmann T, Eysel UT, Faissner A (2012) The laser lesion of the mouse visual cortex as a model to study neural extracellular matrix remodeling during degeneration, regeneration and plasticity of the CNS.Cell Tissue Res 349:133-145.
Purushothaman A, Sugahara K, Faissner A (2012) Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny. J Biol Chem 287:2935-2942.
Karus M, Samtleben S, Busse C, Tsai T, Dietzel ID, Faissner A, Wiese S (2012) Normal Sulphation levels regulate spinal cord neural precursor cell proliferation and differentiation. Neural Dev 7:20.
Hennen E, Faissner A (2012) LewisX: a neural stem cell specific glycan? Int J Biochem Cell Biol 44:830-833.
Geissler M, Faissner A (2012) A new indirect co-culture set up of mouse hippocampal neurons and cortical astrocytes on microelectrode arrays. J Neurosci Methods 204:262-272.
Garwood J, Theocharidis U, Calco V, Dobbertin A, Faissner A (2012) Existence of Tenascin-C Isoforms in Rat that Contain the Alternatively Spliced AD1 Domain are Developmentally Regulated During Hippocampal Development. Cell Mol Neurobiol 32:279-287.
Besser M, Jagatheaswaran M, Reinhard J, Schaffelke P, Faissner A (2012) Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Muller glia by influencing growth factor responsiveness and the extracellular matrix compartment. Dev Biol 369:163-176.

2011

Karus M, Denecke B, ffrench-Constant C, Wiese S, Faissner A (2011) The extracellular matrix molecule tenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification. Development 138: 5321-5331
Pyka M, Wetzel C, Aguado A, Geissler M, Hatt H, Faissner A (2011) Chondroitin sulfate proteoglycans regulate astrocyte-dependent synaptogenesis and modulate synaptic activity in primary embryonic hippocampal neurons. Eur J Neurosci 33:2187-2202.
Pyka M, Busse C, Seidenbecher C, Gundelfinger ED, Faissner A (2011) Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay. Synapse 65:41-53.
Klausmeyer A, Conrad R, Faissner A, Wiese S (2011) Influence of glial-derived matrix molecules, especially chondroitin sulfates, on neurite growth and survival of cultured mouse embryonic motoneurons. J Neurosci Res 89:127-141.
Hennen E, Czopka T, Faissner A (2011) Structurally Distinct LewisX Glycans Distinguish Subpopulations of Neural Stem/Progenitor Cells. J Biol Chem 286:16321-16331.
Bockelmann J, Klinkhammer K, von Holst A, Seiler N, Faissner A, Brook GA, Klee D, Mey J (2011) Functionalization of Electrospun Poly(epsilon-Caprolactone) Fibers with the Extracellular Matrix-Derived Peptide GRGDS Improves Guidance of Schwann Cell Migration and Axonal Growth. Tissue Eng Part A 17(3-4) 475-486.

2010

Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Gotz M, Faissner A (2010) Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny. Stem Cells 28:775-787.
Sirko S, Akita K, Von Holst A, Faissner A (2010) Structural and functional analysis of chondroitin sulfate proteoglycans in the neural stem cell niche. Methods Enzymol 479:37-71.
Muth-Kohne E, Pachernegg S, Karus M, Faissner A, Hollmann M (2010) Expression of NMDA receptors and Ca2+-impermeable AMPA receptors requires neuronal differentiation and allows discrimination between two different types of neural stem cells. Cell Physiol Biochem 26:935-946.
Faissner A, Pyka M, Geissler M, Sobik T, Frischknecht R, Gundelfinger ED, Seidenbecher C (2010) Contributions of astrocytes to synapse formation and maturation - Potential functions of the perisynaptic extracellular matrix. Brain Res Rev 63:26-38.
Dobbertin A, Czvitkovich S, Theocharidis U, Garwood J, Andrews MR, Properzi F, Lin R, Fawcett JW, Faissner A (2010) Analysis of combinatorial variability reveals selective accumulation of the fibronectin type III domains B and D of tenascin-C in injured brain. Exp Neurol 225:60-73.
Czopka T, von Holst A, ffrench-Constant C, Faissner A (2010) Regulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiation. J Neurosci 30:12310-12322.
Afshari FT, Kwok JC, Andrews MR, Blits B, Martin KR, Faissner A, Ffrench-Constant C, Fawcett JW (2010) Integrin activation or alpha 9 expression allows retinal pigmented epithelial cell adhesion on Bruch's membrane in wet age-related macular degeneration. Brain 133:448-464.

2009

von Holst A, Faissner A (2009) Im gemachten Nest – Struktur und Funktionen neuraler Stammzellnischen / Pampered in the nest – Structure and Functions of Neural Stem Cell Niches. Neuroforum XV:44 - 55.
Sirko S, Neitz A, Mittmann T, Horvat-Brocker A, von Holst A, Eysel UT, Faissner A (2009) Focal laser-lesions activate an endogenous population of neural stem/progenitor cells in the adult visual cortex. Brain 132:2252-2264.
Siddiqui S, Horvat-Broecker A, Faissner A (2009) Comparative screening of glial cell types reveals extracellular matrix that inhibits retinal axon growth in a chondroitinase ABC-resistant fashion. Glia 57:1420-1438.
Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M (2009) Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia 57:1630-1647.
Reinhard J, Horvat-Brocker A, Illes S, Zaremba A, Knyazev P, Ullrich A, Faissner A (2009) Protein tyrosine phosphatases expression during development of mouse superior colliculus. Exp Brain Res 199:279-297.
Michele M, Faissner A (2009) Tenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C. Mol Cell Neurosci 41:397-408.
Faissner A (2009) Axon guidance. In: Neuroglia, 2nd Edition (Kettenmann H, Ransom BR, eds), p Chapter 32. Oxford: Oxford Scholarship Online (http://www.oxfordscholarship.com/).
Faissner A (2009) Axon guidance by glia. In: Developmental Neurobiology (Lemke G, ed), pp 393-402: Academic Press
Faissner A (2009) Axon guidance by glia [Article 1758]. In: Encyclopedia of Neuroscience (Squire LR, ed), pp 1063-1072: Oxford: Academic Press.
Czopka T, Von Holst A, Schmidt G, Ffrench-Constant C, Faissner A (2009) Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. Glia 57:1790-1801.
Czopka T, Hennen E, von Holst A, Faissner A (2009) Novel conserved oligodendrocyte surface epitope identified by monoclonal antibody 4860. Cell Tissue Res 338:161-170.
Besser M, Horvat-Bröcker A, Eysel UT, Faissner A (2009) Differential expression of receptor protein tyrosine phosphatases accompanies the reorganisation of the retina upon laser lesion. Exp Brain Res 198:37-47.
Andrews MR, Czvitkovich S, Dassie E, Vogelaar CF, Faissner A, Blits B, Gage FH, ffrench-Constant C, Fawcett JW (2009) Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci 29:5546-5557.

2008

Siddiqui S, Horvat-Brocker A, Faissner A (2008) The glia-derived extracellular matrix glycoprotein tenascin-C promotes embryonic and postnatal retina axon outgrowth via the alternatively spliced fibronectin type III domain TNfnD. Neuron Glia Biol 4:271-283.
Moritz S, Lehmann S, Faissner A, von Holst A (2008) An induction gene trap screen in neural stem cells reveals an instructive function of the niche and identifies the splicing regulator sam68 as a tenascin-C-regulated target gene. Stem Cells 26:2321-2331.
Horvat-Brocker A, Reinhard J, Illes S, Paech T, Zoidl G, Harroch S, Distler C, Knyazev P, Ullrich A, Faissner A (2008) Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Neuroscience 152:618-645.
Akita K, von Holst A, Furukawa Y, Mikami T, Sugahara K, Faissner A (2008) Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance. Stem Cells 26:798-809.

2007

von Holst A, Egbers U, Prochiantz A, Faissner A (2007) Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6. J Biol Chem 282:9172-9181.
Sirko S, von Holst A, Wizenmann A, Gotz M, Faissner A (2007) Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells. Development 134:2727-2738.
Klausmeyer A, Garwood J, Faissner A (2007) Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system. J Comp Neurol 504:659-679.
Kazanis I, Belhadi A, Faissner A, Ffrench-Constant C (2007) The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C. J Neurosci 27:13991-13996.
Heck N, Garwood J, Dobbertin A, Calco V, Sirko S, Mittmann T, Eysel UT, Faissner A (2007) Evidence for distinct leptomeningeal cell-dependent paracrine and EGF-linked autocrine regulatory pathways for suppression of fibrillar collagens in astrocytes. Mol Cell Neurosci 36:71-85.

2006

von Holst A, Sirko S, Faissner A (2006) The unique 473HD-Chondroitinsulfate Epitope is Expressed by Radial Glia and Involved in Neural Precursor Cell Proliferation. Journal of Neuroscience 26:4082-4094.
Faissner A, Heck N, Dobbertin A, Garwood J (2006) DSD-1-Proteoglycan/Phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues. Adv Exp Med Biol 557:25-53.

2005

Ito Y, Hikino M, Yajima Y, Mikami T, Sirko S, von Holst A, Faissner A, Fukui S, Sugahara K (2005) Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library. Glycobiology 15:593-603.
Heck N, Klausmeyer A, Faissner A, Garwood J (2005) Cortical neurons express PSI, a novel isoform of phosphacan/RPTPbeta. Cell Tissue Res 321:323-333.
Faissner A, Heck N, Dobbertin A, Garwood J (2005) DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues. In: Brain Repair (Bahr M, ed): Plenum Publishers Corporation.
Faissner A (2005) Axon guidance. In: Neuroglia, Second Edition Edition (Kettenmann H, Ransom BR, eds), pp 405-417. Oxford • New York: Oxford University Press.
Bao X, Mikami T, Yamada S, Faissner A, Muramatsu T, Sugahara K (2005) Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains. J Biol Chem 280:9180-9191.

2004

Heck N, Garwood J, Loeffler JP, Larmet Y, Faissner A (2004) Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy. Neuroscience 129:309-324.
Garwood J, Garcion E, Dobbertin A, Heck N, Calco V, ffrench-Constant C, Faissner A (2004) The extracellular matrix glycoprotein Tenascin-C is expressed by oligodendrocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet-derived growth factor. Eur J Neurosci 20:2524-2540.
Garcion E, Halilagic A, Faissner A, ffrench-Constant C (2004) Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development 131:3423-3432.
Camand E, Morel MP, Faissner A, Sotelo C, Dusart I (2004) Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord. Eur J Neurosci 20:1161-1176.

2003

Hikino M, Mikami T, Faissner A, Vilela-Silva AC, Pavao MS, Sugahara K (2003) Oversulfated dermatan sulfate exhibits neurite outgrowth-promoting activity toward embryonic mouse hippocampal neurons: implications of dermatan sulfate in neuritogenesis in the brain. J Biol Chem 278:43744-43754.
Heck N, Garwood J, Schutte K, Fawcett J, Faissner A (2003) Astrocytes in culture express fibrillar collagen. Glia 41:382-392.
Garwood J, Heck N, Reichardt F, Faissner A (2003) Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J Biol Chem 278:24164-24173.
Faissner A (2003) Räume der Begegnung: wo Nervenbahnen entstehen, wachsen und sich verändern. Rubin Sonderheft 2003:41-45.
Dobbertin A, Rhodes KE, Garwood J, Properzi F, Heck N, Rogers JH, Fawcett JW, Faissner A (2003) Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia. Mol Cell Neurosci 24:951-971.

2002

Rigato F, Garwood J, Calco V, Heck N, Faivre-Sarrailh C, Faissner A (2002) Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/contactin. J Neurosci 22:6596-6609.
Garcion E, Faissner A, ffrench-Constant C (2002) La ténascine-C: une molécule de la matrice extracellulaire impliquée dans le développement du système nerveux central. Medecine Sciences 18:982-988.

2001

Riedl S, Tandara A, Reinshagen M, Hinz U, Faissner A, Bodenmuller H, Buhr HJ, Herfarth C, Moller P (2001) Serum tenascin-C is an indicator of inflammatory bowel disease activity. Int J Colorectal Dis 16:285-291.
Joester A, Faissner A (2001) The structure and function of tenascins in the nervous system. Matrix Biol 20:13-22.
Garwood J, Rigato F, Heck N, Faissner A (2001) Tenascin glycoproteins and the complementary ligand DSD-1-PG/ phosphacan--structuring the neural extracellular matrix during development and repair. Restor Neurol Neurosci 19:51-64.
Garwood J, Heck N, Rigato F, Faissner A (2001) The extracellular Matrix in neural Development, Plasticity and Regeneration. In: Neural Environment, The Brain Homeostasis in Health and Disease (Walz W, ed), pp 109-158. Totowa NJ: Humana Press.
Garcion E, Faissner A, ffrench-Constant C (2001) Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration. Development 128:2485-2496.
Adamsky K, Schilling J, Garwood J, Faissner A, Peles E (2001) Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Oncogene 20:609-618.

1999

Schoser BG, Faissner A, Goebel HH (1999) Immunolocalization of tenascin-C in human type II fiber atrophy. J Mol Neurosci 13:167-175.
Kiernan BW, Garcion E, Ferguson J, Frost EE, Torres EM, Dunnett SB, Saga Y, Aizawa S, Faissner A, Kaur R, Franklin RJ, ffrench-Constant C (1999) Myelination and behaviour of tenascin-C null transgenic mice. Eur J Neurosci 11:3082-3092.
Joester A, Faissner A (1999) Evidence for combinatorial variability of tenascin-C isoforms and developmental regulation in the mouse central nervous system. J Biol Chem 274:17144-17151.
Garwood J, Schnadelbach O, Clement A, Schutte K, Bach A, Faissner A (1999) DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage. J Neurosci 19:3888-3899.
Fidler PS, Schuette K, Asher RA, Dobbertin A, Thornton SR, Calle-Patino Y, Muir E, Levine JM, Geller HM, Rogers JH, Faissner A, Fawcett JW (1999) Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: the major axon-inhibitory proteoglycan is NG2. J Neurosci 19:8778-8788.
Dueck M, Riedl S, Hinz U, Tandara A, Moller P, Herfarth C, Faissner A (1999) Detection of tenascin-C isoforms in colorectal mucosa, ulcerative colitis, carcinomas and liver metastases. Int J Cancer 82:477-483.
Clement AM, Sugahara K, Faissner A (1999) Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons. Neurosci Lett 269:125-128.

1998

Zahn M, Gotz B, Faissner A, Seeger S (1998) Optical tweezers as a tool for the functional analysis of neuronal cell surface receptors. In: Conference on Biomedical Systems and Technologies II (Croitoru NI, Myagi M, Baldini F, Pratesi R, Seeger S, Frenz M, Dickinson MR, eds), pp 156-167. San Remo, Italy: PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE-INT), Vol. 3199
Schnadelbach O, Mandl C, Faissner A (1998) Expression of DSD-1-PG in primary neural and glial-derived cell line cultures, upregulation by TGF-beta, and implications for cell-substrate interactions of the glial cell line Oli-neu. Glia 23:99-119.
Riedl S, Kadmon M, Tandara A, Hinz U, Moller P, Herfarth C, Faissner A (1998) Mucosal tenascin C content in inflammatory and neoplastic diseases of the large bowel. Dis Colon Rectum 41:86-92.
Nadanaka S, Clement A, Masayama K, Faissner A, Sugahara K (1998) Characteristic hexasaccharide sequences in octasaccharides derived from shark cartilage chondroitin sulfate D with a neurite outgrowth promoting activity. J Biol Chem 273:3296-3307.
Kwei SL, Clement A, Faissner A, Brandt R (1998) Differential interactions of MAP2, tau and MAP5 during axogenesis in culture. Neuroreport 9:1035-1040.
Clement AM, Nadanaka S, Masayama K, Mandl C, Sugahara K, Faissner A (1998) The DSD-1 carbohydrate epitope depends on sulfation, correlates with chondroitin sulfate D motifs, and is sufficient to promote neurite outgrowth. J Biol Chem 273:28444-28453.

1997

Theodosis DT, Pierre K, Cadoret MA, Allard M, Faissner A, Poulain DA (1997) Expression of high levels of the extracellular matrix glycoprotein, tenascin-C, in the normal adult hypothalamoneurohypophysial system. J Comp Neurol 379:386-398.
Talts JF, Eng H, Zhang HY, Faissner A, Ekblom P (1997) Characterization of monoclonal antibodies against tenascin-C: no apparent effect on kidney development in vitro. Int J Dev Biol 41:39-48.
Scheffler B, Faissner A, Beck H, Behle K, Wolf HK, Wiestler OD, Blumcke I (1997) Hippocampal loss of tenascin boundaries in Ammon's horn sclerosis. Glia 19:35-46.
Riedl S, Kadmon M, Tandara A, Hinz U, Moller P, Faissner A (1997) Tenascin-C tissue concentration in inflammatory and neoplastic diseases of the colon mucosa. Anticancer Res 17:3165-3166.
Rauch U, Clement A, Retzler C, Frohlich L, Fassler R, Gohring W, Faissner A (1997) Mapping of a defined neurocan binding site to distinct domains of tenascin-C. J Biol Chem 272:26905-26912.
Gotz M, Bolz J, Joester A, Faissner A (1997) Tenascin-C synthesis and influence on axonal growth during rat cortical development. Eur J Neurosci 9:496-506.
Faissner A (1997) Glial Derived Extracellular matrix Components: Important Roles in Axon Growth and Guidance. The Neuroscientist 3:371-380.
Faissner A (1997) The tenascin gene family in axon growth and guidance. Cell Tissue Res 290:331-341.
Drescher U, Faissner A, Klein R, Rathjen FG, Sturmer C (1997) Axonal growth and pathfinding: from phenomena to molecules. Cell Tissue Res 290:187-188.
Deller T, Haas CA, Naumann T, Joester A, Faissner A, Frotscher M (1997) Up-regulation of astrocyte-derived tenascin-C correlates with neurite outgrowth in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience 81:829-846.

1996

Wintergerst ES, Faissner A, Celio MR (1996) The proteoglycan DSD-1-PG occurs in perineuronal nets around parvalbumin-immunoreactive interneurons of the rat cerebral cortex. Int J Dev Neurosci 14:249-255.
Scholze A, Gotz B, Faissner A (1996) Glial cell interactions with tenascin-C: adhesion and repulsion to different tenascin-C domains is cell type related. Int J Dev Neurosci 14:315-329.
Kiernan BW, Gotz B, Faissner A, ffrench-Constant C (1996) Tenascin-C inhibits oligodendrocyte precursor cell migration by both adhesion-dependent and adhesion-independent mechanisms. Mol Cell Neurosci 7:322-335.
Kettenmann H, Faissner A, Trotter J (1996) Neuron-Glia Interactions in Homeostasis and Degeneration. In: Comprehensive Human Physiology (Greger R, Windhorst U, eds), pp 533-543. Berlin • Heidelberg • New York: Springer.
Kempf M, Clement A, Faissner A, Lee G, Brandt R (1996) Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci 16:5583-5592.
Gotz B, Scholze A, Clement A, Joester A, Schutte K, Wigger F, Frank R, Spiess E, Ekblom P, Faissner A (1996) Tenascin-C contains distinct adhesive, anti-adhesive, and neurite outgrowth promoting sites for neurons. J Cell Biol 132:681-699.
Frost E, Kiernan BW, Faissner A, ffrench-Constant C (1996) Regulation of oligodendrocyte precursor migration by extracellular matrix: evidence for substrate-specific inhibition of migration by tenascin-C. Dev Neurosci 18:266-273.
Faissner A, Kettenmann H, Trotter J (1996) Establishment of Neural Cell Populations and Interneural Connections. In: Comprehensive Human Physiology (Greger R, Windhorst U, eds), pp 603-622. Berlin • Heidelberg • New York: Springer Verlag.
FaIssner A, Gotz B, Joester A, Wigger F, Scholze A, Schutte K (1996) Tenascin-C glycoproteins in neural pattern formation and plasticity. Seminars in the Neurosciences 8:347-356.
Faissner A (1996) The Tenascin Gene Family in Development and Plasticity of Neural Tissue. In: Tenascin and Counteradhesive Molecules of the Extracellular Matrix (Crossin KL, ed), pp 47-87. Amsterdam - Netherlands: Harwood Academic Publishers.
Barker RA, Dunnett SB, Faissner A, Fawcett JW (1996) The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon to the striatum. Exp Neurol 141:79-93.

1995

Steindler DA, Settles D, Erickson HP, Laywell ED, Yoshiki A, Faissner A, Kusakabe M (1995) Tenascin knockout mice: barrels, boundary molecules, and glial scars. J Neurosci 15:1971-1983.
Smith-Thomas LC, Stevens J, Fok-Seang J, Faissner A, Rogers JH, Fawcett JW (1995) Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors. J Cell Sci 108 ( Pt 3):1307-1315.
Riedl S, Bodenmuller H, Hinz U, Holle R, Moller P, Schlag P, Herfarth C, Faissner A (1995) Significance of tenascin serum level as tumor marker in primary colorectal carcinoma. Int J Cancer 64:65-69.
Niquet J, Jorquera I, Faissner A, Ben-Ari Y, Represa A (1995) Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity. J Neurocytol 24:611-624.
Heyman I, Faissner A, Lumsden A (1995) Cell and matrix specialisations of rhombomere boundaries. Dev Dyn 204:301-315.
Gates MA, Thomas LB, Howard EM, Laywell ED, Sajin B, Faissner A, Gotz B, Silver J, Steindler DA (1995) Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres. J Comp Neurol 361:249-266.
Fok-Seang J, Smith-Thomas LC, Meiners S, Muir E, Du JS, Housden E, Johnson AR, Faissner A, Geller HM, Keynes RJ, et al. (1995) An analysis of astrocytic cell lines with different abilities to promote axon growth. Brain Res 689:207-223.
Faissner A, Steindler D (1995) Boundaries and inhibitory molecules in developing neural tissues. Glia 13:233-254.
Faissner A, Schachner M (1995) Tenascin and janusin: glial recognition molecules involved in neural pattern formation and regeneration. In: Neuroglia, First Edition (Kettenmann H, Ransom BR, eds), pp 411-426. New York - Oxford: Oxford University Press.
Faissner A, Gotz B, Joester A, Scholze A (1995) The tenascin gene family - versatile glycoproteins implicated in neural pattern formation and regeneration. Seminars in Developmental Biology 6:139-148.
Brodkey JA, Laywell ED, O'Brien TF, Faissner A, Stefansson K, Dorries HU, Schachner M, Steindler DA (1995) Focal brain injury and upregulation of a developmentally regulated extracellular matrix protein. J Neurosurg 82:106-112.
Braunewell KH, Martini R, LeBaron R, Kresse H, Faissner A, Schmitz B, Schachner M (1995) Up-regulation of a chondroitin sulphate epitope during regeneration of mouse sciatic nerve: evidence that the immunoreactive molecules are related to the chondroitin sulphate proteoglycans decorin and versican. Eur J Neurosci 7:792-804.
Appel F, Holm J, Conscience JF, von Bohlen und Halbach F, Faissner A, James P, Schachner M (1995) Identification of the border between fibronectin type III homologous repeats 2 and 3 of the neural cell adhesion molecule L1 as a neurite outgrowth promoting and signal transducing domain. J Neurobiol 28:297-312.

1994

Ushmorov AG, Furstenberger G, Faissner A, Marks F (1994) Effects of complete and incomplete tumor promoters on hair growth, angiogenesis, and tenascin expression in the skin of NMRI mice. Carcinogenesis 15:2739-2745.
Steindler DA, Faissner A, Harrington KL (1994) A unique mosaic in the visual cortex of the reeler mutant mouse. Cereb Cortex 4:129-137.
Smith-Thomas LC, Fok-Seang J, Stevens J, Du JS, Muir E, Faissner A, Geller HM, Rogers JH, Fawcett JW (1994) An inhibitor of neurite outgrowth produced by astrocytes. J Cell Sci 107 ( Pt 6):1687-1695.
Langenfeld-Oster B, Faissner A, Irintchev A, Wernig A (1994) Polyclonal antibodies against NCAM and tenascin delay endplate reinnervation. J Neurocytol 23:591-604.
Krull CE, Oland LA, Faissner A, Schachner M, Tolbert LP (1994) In vitro analyses of neurite outgrowth indicate a potential role for tenascin-like molecules in the development of insect olfactory glomeruli. J Neurobiol 25:989-1004.
Krull CE, Morton DB, Faissner A, Schachner M, Tolbert LP (1994) Spatiotemporal pattern of expression of tenascin-like molecules in a developing insect olfactory system. J Neurobiol 25:515-534.
Faissner A, Scholze A, Gotz B (1994) Tenascin glycoproteins in developing neural tissues: only decoration? Perspect Dev Neurobiol 2:53-66.
Faissner A, Clement A, Lochter A, Streit A, Mandl C, Schachner M (1994) Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties. J Cell Biol 126:783-799.
Bartsch U, Faissner A, Trotter J, Dorries U, Bartsch S, Mohajeri H, Schachner M (1994) Tenascin demarcates the boundary between the myelinated and nonmyelinated part of retinal ganglion cell axons in the developing and adult mouse. J Neurosci 14:4756-4768.

1993

Irintchev A, Salvini TF, Faissner A, Wernig A (1993) Differential expression of tenascin after denervation, damage or paralysis of mouse soleus muscle. J Neurocytol 22:955-965.
Gates MA, O'Brien TF, Faissner A, Steindler DA (1993) Neuron-glial interactions during the in vivo and in vitro development of the nigrostriatal circuit. J Chem Neuroanat 6:179-189.
Faissner A, Clement A, Gotz B, Joester A, Mandl C, Niederlander C, Schnadelbach O, Scholze A (1993) Tenascin and DSD-1-proteoglycan - extracellular matrix components involved in neural pattern formation and remodeling. In: Biology of Vitronectins and their Receptors (Preissner KT, Rosenblatt S, Kost C, Wegerhoff J, Mosher DF, eds), pp 229-234. Elsevier Publishers Amsterdam - New York - London - Tokyo: Excerpta Medica, International Congress Series.
Faissner A (1993) Kontakte und Bindungen - Zelladhäsion bei Nerven- und Immunzellen. Aus Forschung und Medizin 8:59-70.
Faissner A (1993) Tenascin glycoproteins in neural pattern formation: facets of a complex picture. Perspect Dev Neurobiol 1:155-164.
Ard MD, Schachner M, Rapp JT, Faissner A (1993) Growth and degeneration of axons on astrocyte surfaces: effects on extracellular matrix and on later axonal growth. Glia 9:248-259.

1992

Riedl SE, Faissner A, Schlag P, Von Herbay A, Koretz K, Moller P (1992) Altered content and distribution of tenascin in colitis, colon adenoma, and colorectal carcinoma. Gastroenterology 103:400-406.
Riedl S, Moller P, Faissner A, Schlag P (1992) Induction and altered distribution of tenascin in the basal lamina of colorectal adenomas and carcinomas. Exs 61:277-281.
O'Brien TF, Faissner A, Schachner M, Steindler DA (1992) Afferent-boundary interactions in the developing neostriatal mosaic. Brain Res Dev Brain Res 65:259-267.
Laywell ED, Dorries U, Bartsch U, Faissner A, Schachner M, Steindler DA (1992) Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. Proc Natl Acad Sci U S A 89:2634-2638.
Husmann K, Faissner A, Schachner M (1992) Tenascin promotes cerebellar granule cell migration and neurite outgrowth by different domains in the fibronectin type III repeats. J Cell Biol 116:1475-1486.
Bartsch S, Bartsch U, Dorries U, Faissner A, Weller A, Ekblom P, Schachner M (1992) Expression of tenascin in the developing and adult cerebellar cortex. J Neurosci 12:736-749.

1991

Riedl S, Moller P, Faissner A, Schlag P (1991) Tenascin - A New Tumor marker for Neoplasias of the Colorectum. In: Tumor Associated Antigens, Oncogenes, Receptors, Cytokines in Tumor Diagnosis and Therapy at the Begining of the Nineties. 6th Symposium on Tumor Markers (Klapdor R, ed), pp 479-482. Hamburg: W. Zuckschwerdt Verlag GmbH, München, Wien.
Lochter A, Vaughan L, Kaplony A, Prochiantz A, Schachner M, Faissner A (1991) J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth. J Cell Biol 113:1159-1171.
Ard MD, Faissner A (1991) Components of astrocytic extracellular matrix are regulated by contact with axons. Ann N Y Acad Sci 633:566-569.

1990

Streit A, Faissner A, Gehrig B, Schachner M (1990) Isolation and biochemical characterization of a neural proteoglycan expressing the L5 carbohydrate epitope. J Neurochem 55:1494-1506.
Steindler DA, O'Brien TF, Laywell E, Harrington K, Faissner A, Schachner M (1990) Boundaries during normal and abnormal brain development: in vivo and in vitro studies of glia and glycoconjugates. Exp Neurol 109:35-56.
Schachner M, Antonicek H, Fahrig T, Faissner A, Fischer G, Künemund V, Martini R, Meyer A, Persohn E, Pollerberg E, Probstmeier R, Sadoul K, Sadoul R, Seilheimer B, Thor G (1990) Families of Neural Cell Adhesion Molecules. In: Morphoregulatory Molecules (Edelman GM, Cunningham BA, Thiery J-P, eds), pp 443-468. New York • Chichester • Brisbane • Toronto • Singapore: John Wiley & Sons.
Miragall F, Kadmon G, Faissner A, Antonicek H, Schachner M (1990) Retention of J1/tenascin and the polysialylated form of the neural cell adhesion molecule (N-CAM) in the adult olfactory bulb. J Neurocytol 19:899-914.
Martini R, Schachner M, Faissner A (1990) Enhanced expression of the extracellular matrix molecule J1/tenascin in the regenerating adult mouse sciatic nerve. J Neurocytol 19:601-616.
Faissner A, Kruse J, Kuhn K, Schachner M (1990) Binding of the J1 adhesion molecules to extracellular matrix constituents. J Neurochem 54:1004-1015.
Faissner A, Kruse J (1990) J1/tenascin is a repulsive substrate for central nervous system neurons. Neuron 5:627-637.
Fahrig T, Schmitz B, Weber D, Kucherer-Ehret A, Faissner A, Schachner M (1990) Two Monoclonal Antibodies Recognizing Carbohydrate Epitopes on Neural Adhesion Molecules Interfere with Cell Interactions. Eur J Neurosci 2:153-161.
Akhurst RJ, Lehnert SA, Faissner A, Duffie E (1990) TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development 108:645-656.

1989

Stern CD, Norris WE, Bronner-Fraser M, Carlson GJ, Faissner A, Keynes RJ, Schachner M (1989) J1/tenascin-related molecules are not responsible for the segmented pattern of neural crest cells or motor axons in the chick embryo. Development 107:309-319.
Steindler DA, Faissner A, Schachner M (1989) Brain "Cordones": Transient Boundaries of Glia and Adhesion Molecules that define Developing Functional Units. Comments Developmental Neurobiology 1:29-60.
Steindler DA, Cooper NG, Faissner A, Schachner M (1989) Boundaries defined by adhesion molecules during development of the cerebral cortex: the J1/tenascin glycoprotein in the mouse somatosensory cortical barrel field. Dev Biol 131:243-260.
Faissner A (1989) Cell-cell adhesion in the nervous system--structural groups emerge. Bioessays 10:79-81.

1988

Sadoul K, Sadoul R, Faissner A, Schachner M (1988) Biochemical characterization of different molecular forms of the neural cell adhesion molecule L1. J Neurochem 50:510-521.
Faissner A, Kruse J, Chiquet-Ehrismann R, Mackie E (1988) The high-molecular-weight J1 glycoproteins are immunochemically related to tenascin. Differentiation 37:104-114.

1987

Kucherer A, Faissner A, Schachner M (1987) The novel carbohydrate epitope L3 is shared by some neural cell adhesion molecules. J Cell Biol 104:1597-1602.
Faissner A (1987) Functional and Structural Characterisation of Cell Adhesion Molecules of the L2/HNK-1 Family. In: Metabolism and Development of the Nervous System (Tucek S, ed), pp 3-7. Prague: Academia.
Faissner A (1987) Monoclonal antibody detects carbohydrate microheterogeneity on the murine cell adhesion molecule L1. Neurosci Lett 83:327-332.

1985

Schachner M, Faissner A, Fischer G, Keilhauer G, Kruse J, Künemund V, Lindner J, Wernecke H (1985) Functional and Structural Aspects of the Cell Surface in Mammalian Nervous System Development In: The Cell in Contact - Adhesions and Junctions as Morphogenetic Determinants (Edelman GM, Thiery J-P, eds), pp 257-275. New York • Chichester • Brisbane • Toronto • Singapore: John Wiley & Sons.
Kruse J, Keilhauer G, Faissner A, Timpl R, Schachner M (1985) The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 family. Nature 316:146-148.
Keilhauer G, Faissner A, Schachner M (1985) Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies. Nature 316:728-730.
Faissner A, Teplow DB, Kubler D, Keilhauer G, Kinzel V, Schachner M (1985) Biosynthesis and membrane topography of the neural cell adhesion molecule L1. Embo J 4:3105-3113.
Bock E, Richter-Landsberg C, Faissner A, Schachner M (1985) Demonstration of immunochemical identity between the nerve growth factor-inducible large external (NILE) glycoprotein and the cell adhesion molecule L1. Embo J 4:2765-2768.

1984

Mehrke G, Jockusch H, Faissner A, Schachner M (1984) Synapse formation and synaptic activity in mammalian nerve-muscle co-culture are not inhibited by antibodies to neural cell adhesion molecule L1. Neurosci Lett 44:235-239.
Kruse J, Mailhammer R, Wernecke H, Faissner A, Sommer I, Goridis C, Schachner M (1984) Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1. Nature 311:153-155.
Faissner A, Kruse J, Nieke J, Schachner M (1984) Expression of neural cell adhesion molecule L1 during development, in neurological mutants and in the peripheral nervous system. Brain Res 317:69-82.
Faissner A, Kruse J, Goridis C, Bock E, Schachner M (1984) The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2. Embo J 3:733-737.

1983

Schachner M, Faissner A, Kruse J, Lindner J, Meier DH, Rathjen FG, Wernecke H (1983) Cell-type specificity and developmental expression of neural cell-surface components involved in cell interactions and of structurally related molecules. Cold Spring Harb Symp Quant Biol 48 Pt 2:557-568.

1982

Flugel RM, Faissner A, Koch HG, Darai G (1982) Analysis of Tupaia herpesvirus proteins by one- and two-dimensional gel electrophoresis. Dev Biol Stand 52:53-65.
Faissner A, Darai G, Flugel RM (1982) Analysis of polypeptides of the tree shrew (Tupaia) herpesvirus by gel electrophoresis. J Gen Virol 58 Pt 1:139-148.
Darai G, Matz B, Delius H, Faissner A, Flugel RM (1982) An Adenovirus of the Tree Shrew: Properties of the Virus. Microbiologica 5:109-120.

1980

Faissner A, Darai G, Flugel RM (1980) Identification of polypeptides of the tree shrew (Tupaia) adenovirus. Intervirology 14:272-276.

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Andreas Faissner

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Tel.: +49 (0)234 / 32-28851
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