Reviews and articles:
REVIEWS:
Schöneborn, H., Raudzus, F., Coppey, M., Neumann, S., Heumann, R. (2018) Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons. Int. J. Mol. Sci. 19(12): 4052. DOI: 10.3390/ijms19124052
Athanasopoulos, P.S., Heumann, R., Kortholt A. (2018) The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2. Biol. Chem. 27; 399: 643-647. DOI: 10.1515/hsz-2017-0332
Serchov, T., Heumann, R. (2018) Ras Activity Tunes the Period and Modulates the Entrainment of the Suprachiasmatic Clock. Front. Neurol. 8: 264. DOI: 10.3389/fneur.2017.00264
Schöpel, M., Potheraveedu, V.N., Al-Harthy, T., Abdel-Jalil, R., Heumann, R., Stoll, R. (2017) The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function. Biol. Chem. 398: 577-588. DOI: 10.1515/hsz-2016-0276
Potheraveedu, V.N., Schöpel, M., Stoll, R., Heumann, R. (2017) Rheb in neuronal degeneration, regeneration, and connectivity. Biol. Chem. 398: 589-606. DOI: 10.1515/hsz-2016-0312
Serchov, T., Heumann, R., van Calker, D. and Biber, K. (2016) Signaling pathways regulating Homer1a expression: implications for antidepressant therapy. Biol. Chem. 397, 207-214
Heumann, R., Moratalla, R., Herrero, M. T., Chakrabarty, K., Drucker-Colín, R., Garcia-Montes, J. R., Simola, N. and Morelli, M. (2014). Dyskinesia in Parkinson's disease: mechanisms and current non pharmacological interventions. Journal of Neurochemistry, DOI: 10.1111/jnc.12751
Damen, D. and Heumann, R.(2013). MeCP2 phosphorylation in the brain: from transcription to behavior. Biol. Chem. 394, 1595–1605.
Kovtun, A., Heumann, R., and Epple, M. (2009). Calcium phosphate nanoparticles for the transfection of cells. Bio-Medical Materials and Engineering 19, 241–247.
Chakrabarty, K. and Heumann, R. (2008). Prospective of Ras signaling in stem cells. Biological Chemistry 389, 791–798.
IDietzel, I. D., Zhong, J. and Heumann, R. (1997). The Role of Glia in Neuroprotection. In: Neuroprotection in CNS Diseases, pages 285-303. Edited by P. R. Bär and M.F. Beal. Marcel Dekker, Inc. New York.
Heumann, R. (1994). Neurotrophin signalling. Current Opinion in Neurobiology 4, 668-679.
ARTICLES:
Schöneborn, H., Raudzus, F., Secret, E., Otten, N., Michel, A., Fresnais, J., Ménager, C., Siaugue, J.-M., Zaehres, H., Dietzel, I.D., Heumann, R. (2019) Novel tools towards magnetic guidance of neurite growth: (I) Guidance of magnetic nanoparticles into neurite extensions of induced human neurons and in vitro functionalization with RAS regulating proteins. J. Funct. Biomater. 10(3): 32. DOI: 10.3390/jfb10030032
Paliga, D., Raudzus, F., Leppla, S.H., Heumann, R., Neumann, S. (2018) Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells. Mol. Neurobiol. DOI: 10.1007/s12035-018-1311-6
Heumann, R. (2018) Highlight Issue 'Molecular Basis of Life 2017' Biol. Chem. 399:621-622. DOI: 10.1515/hsz-2018-0248
Serdar, M., Herz, J., Kempe, K., Winterhager, E., Jastrow, H., Heumann, R., Felderhoff-Müser, U., Bendix, I. (2018) Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury. Front. Neurol. 21; 9: 175. DOI: 10.3389/fneur.2018.00175
Islam, M.S., Nolte, H., Jacob, W., Ziegler, A.B., Pütz, S., Grosjean, Y., Szczepanowska, K., Trifunovic, A., Braun, T., Heumann, H., Heumann, R., Hovemann, B., Moore, D.J., Krüger, M. (2016) Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum. Mol. Genet. 25: 5365-5382. DOI: 10.1093/hmg/ddw352
Athanasopoulos, P.S., Jacob, W., Neumann, S., Kutsch, M., Wolters, D., Tan, E.K., Bichler, Z., Herrmann, C., and Heumann, R. (2016) Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2. Biol. Chem. 397(6): 541-554. DOI: 10.1515/hsz-2015-0189
Heumann R. (2016) Highlight: Perspectives of molecular neuroscience in health and disease. Biol Chem. 397, 175
Serdar, M., Herz, J., Kempe, K., Lumpe, K., Reinboth, B.S., Sizonenko, S.V., Hou, X., Herrmann, R., Hadamitzky, M., Heumann, R., Hansen, W., Sifringer, M., van de Looij, Y., Felderhoff-Müser, U. and Bendix, I. (2016) Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. Brain Behav Immun. 52 , 106-190.
Serchov, T., Jilg, A., Wolf, C.T., Radtke, I., Stehle, J. and Heumann, R., (2015). Ras Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics. Molecular Neurobiology; DOI: 10.1007/s12035-015-9135-0
Schöpel, M., Jockers, K. F., Düppe, P. M., Autzen, J., Potheraveedu, V. N., Ince, S., Yip, K. T., Heumann, R., Herrmann, C., Scherkenbeck, J. and Stoll, R. (2013). Bisphenol A Binds to Ras Proteins and Competes with Guanine Nucleotide Exchange: Implications for GTPase-Selective Antagonists.J. Med. Chem. 56, 9664–9672. Full text.pdf
Ehrkamp, A., Herrmann, C., Stoll, R. I. and Heumann, R. (2013). Ras and Rheb Signaling in Survival and Cell Death. Cancers 5, 639-661. Full text.pdf
Drost, J., Nonis, D., Eich, F., Leske, O., Damrath, E., Brunt, E. R., Lastres-Becker, I., Heumann, R., Nowock, J., Auburger, G. (2013). Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling. J Mol Neurosci 51, 68 -81.
Nickel, K. F., Laux, V., Heumann, R., von Degenfeld, G. (2013). Thrombin Has Biphasic Effects on the Nitric Oxide-cGMP Pathway in Endothelial Cells and Contributes to Experimental Pulmonary Hypertension. PLOS ONE 8(6): e63504. PONE-D-11-11010R3. Full text. pdf
Kovtun, A., Neumann, S., Neumeier, M., Urch, H., Heumann, R., Gepp, M., Wallat, K., Koeller, M., Zimmermann, H., Epple, M. (2013). Nanoparticle-Mediated Gene Transfer From Electrophoretically Coated Metal Surfaces. J. Phys. Chem. B 117, 1550−1555.
Bendix, I., Weichelt, U., Strasser, K., Serdar, M., Endesfelder, S., von Haefen, C., Heumann, R., Ehrkamp, A., Felderhoff-Mueser, U., Sifringer, M. (2012). Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brain. Brain Research 1484, 68-75.
Bendix, I., Schulze, C., von Haefen, C., Gellhaus, A., Endesfelder, S., Heumann, R., Felderhoff-Mueser, U., Sifringer, M. (2012). Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity. Int. J. Mol. Sci. 13, 12939-12951.
Imielski, Y., Schwamborn, J. C., Lüningschrör, P., Heimann, P., Holzberg, M., Werner, H., Leske, O., Püschel, A. W., Memet, S., Heumann, R., Israel, A., Kaltschmidt, C., Kaltschmidt, B. (2012). Regrowing the Adult Brain: NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus. PLoS ONE 7(2): e30838. doi:10.1371/journal.pone.0030838. Full text pdf
Gasser, G., Pinto, A., Neumann, S., Sosniak, A. M., Seitz, M., Merz, K., Heumann, R., Metzler-Nolte, N. (2012). Synthesis, Characterisation and Bioimaging of a Fluorescent Rhenium-Containing PNA Bioconjugate. Dalton Transaction, 41, 2304-2313 . Full text pdf
Gasser, G., Neumann, S., Ott, I., Seitz, M., Heumann, R., Metzler-Nolte, N. (2011). Preparation and Biological Evaluation of Di-Hetero-Organometallic-Containing PNA Bioconjugates. Eur. J. Inorg. Chem. 36, 5471-5478. Full text pdf
Lafenetre, P., Leske, O., Wahle, P., Heumann, R. (2011).The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance. Front. Neurosci. 5:51.. Full text pdf
Manns, M., Leske, O., Gottfried, S., Bichler, Z., Lafenetre, P., Wahle, P., and Heumann, R. (2011). Role of neuronal ras activity in adult hippocampal neurogenesis and cognition. Front Neurosci 5:18. Full text pdf
Damen, D., Leske, O., and Heumann, R. (2010). Neuronal activation of ras regulates the adverse phenotype in a mouse model of Rett Syndrome. International Journal of Developmental Neuroscience 28, 699–700.
Epple, M., Ganesan, K., Heumann, R., Klesing, J., Kovtun, A., Neumann, S., and Sokolova, V. (2010). Application of calcium phosphate nanoparticles in biomedicine. Journal of Materials Chemistry 20, 18–23.
Karassek, S., Berghaus, C., Schwarten, M., Goemans, C.G., Ohse, N., Kock, G., Jockers, K., Neumann, S., Gottfried, S., Herrmann, C., Heumann, R., and Stoll, R. (2010). Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem 285, 33979–33991. Full text pdf
Klesing, J., Chernousova, S., Kovtun, A., Neumann, S., Ruiz, L., Gonzalez-Calbet, J.M., Vallet-Regi, M., Heumann, R., and Epple, M. (2010). An injectable paste of calcium phosphate nanorods, functionalized with nucleic acids, for cell transfection and gene silencing. Journal of Materials Chemistry 20, 6144–6148.
Kock, G., Dicks, M., Heumann, R., Erdmann, K. S., and Stoll, R. (2010). Sequence-specific H-1, C-13, and N-15 assignment of the extended PDZ3 domain of the protein tyrosine phosphatase basophil-like PTP-BL. Biomolecular NMR Assignments 4, 199–202.
Lafenetre, P., Leske, O., Ma-Hogemeie, Z., Haghikia, A., Bichler, Z., Wahle, P., and Heumann, R. (2010). Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis. Front Behav Neurosci 3, 34.
Leske, O., Bichler, Z., and Heumann, R. (2010). Antidepressant-like features of mice with transgenic activation of Ras in differentiated neurons. European Neuropsychopharmacology 20, S358-S359.
Manns, M., Bichler, Z., Leske, O., and Heumann, R. (2010). Neuronal Ras activation inhibits adult hippocampal progenitor cell division and impairs spatial short-term memory. Genes Brain and Behavior 9, 525–536.
Sokolova, V., Neumann, S., Kovtun, A., Chernousova, S., Heumann, R., and Epple, M. (2010). An outer shell of positively charged poly(ethyleneimine) strongly increases the transfection efficiency of calcium phosphate/DNA nanoparticles. Journal of Materials Science 45, 4952–4957.
Adiguzel, Y., Hippe, S., Hauswald, H.J., Stoll, R., and Heumann, R. (2009). Phosphorus NMR of model membrane interaction with nitric oxide. FEBS Journal 276, 230.
Kovtun, A., Heumann, R., and Epple, M. (2009). Calcium phosphate nanoparticles for the transfection of cells. Bio-Medical Materials and Engineering 19, 241–247.
Makwana, M., Serchov, T., Hristova, M., Bohatschek, M., Gschwendtner, A., Kalla, R., Liu, Z., Heumann, R., and Raivich, G. (2009). Regulation and function of neuronal GTP-Ras in facial motor nerve regeneration. Journal of Neurochemistry 108, 1453–1463.
Neumann, S., Kovtun, A., Dietzel, I.D., Epple, M., and Heumann, R. (2009). The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection. Biomaterials 30, 6794–6802.
Patz, S., Colovic, C., Wawro, S., Lafenetre, P., Leske, O., Heumann, R., Schoenfelder, S., Tomaschewski, J., Raek, A., and Wahle, P. (2009). Interneuronal growth and expression of interneuronal markers in visual cortex of mice with transgenic activation of Ras. Experimental Brain Research 199, 265–278.
Stenzel, N., Fetzer, C.P., Heumann, R., and Erdmann, K.S. (2009). PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. Journal of Cell Science 122, 3374–3384.
Chakrabarty, K., and Heumann, R. (2008). Prospective of Ras signaling in stem cells. Biological Chemistry 389, 791–798.
Ganesan, K., Kovtun, A., Neumann, S., Heumann, R., and Epple, M. (2008). Calcium phosphate nanoparticles: colloidally stabilized and made fluorescent by a phosphate-functionalized porphyrin. Journal of Materials Science 18, 3655–3661.
Mann, S.A., Versmold, B., Marx, R., Stahlhofen, S., Dietzel, I.D., Heumann, R., and Berger, R. (2008). Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. Journal of Neuroinflammation 5, 39.
Berghaus, C., Schwarten, M., Heumann, R., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the GTPase rRheb in its GDP-bound form. Biomolecular NMR Assignments 1, 45–47.
Chakrabarty, K., Serchov, T., Mann, S.A., Dietzel, I.D., and Heumann, R. (2007). Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. European Journal of Neuroscience 25, 1971–1981.
Fetzer, C.P., Sauvageau, J., Kock, G., Berghaus, C., Bangert, J.-A., Dicks, M., Heumann, R., Erdmann, K.S., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL. Biomolecular NMR Assignments 1, 151–153.
Gaertner, U., Alpar, A., Heumann, R., and Arendt, T. (2007). Effects of enhanced Ras activity on neuronal morphology in vivo. Journal of Neural Transmission 114, CXXII–CXXIII.
Grote-Westrick, C., and Heumann, R. (2007). Nitric oxide regulates membrane fluidity with implications on cell migration and endocytosis. Journal of Neurochemistry 102, 260.
Sandoval, M., Sandoval, R., Thomas, U., Spilker, C., Smalla, K.-H., Falcon, R., Marengo, J.J., Calderon, R., Saavedra, V., Heumann, R., Bronfman, F., Garner, C.C., Gundelfinger, E.D., and Wyneken, U. (2007). Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes. Journal of Neurochemistry 101, 1672–1684.
Schwarten, M., Berghaus, C., Heumann, R., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the activated 21 kDa GTPase rRheb. Biomolecular NMR Assignments 1, 105–108.
Sokolova, V., Kovtun, A., Heumann, R., and Epple, M. (2007). Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. Journal of Biological Inorganic Chemistry 12, 174–179.
Sokolova, V., Kovtun, A., Prymak, O., Meyer-Zaika, W., Kubareva, E.A., Romanova, E.A., Oretskaya, T.S., Heumann, R., and Epple, M. (2007). Functionalisation of calcium phosphate nanoparticles by oligonucleotides and their application for gene silencing. Journal of Materials Science 17, 721–727.