Publications

2024

Preprint: PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities.
Fink R., Imai S., Gockel N., Lauer G., Kim R., Wietek J., Lamothe-Molina P.J., Fuhrmann F., Mittag M., Ziebarth T., Canziani A., Kubitschke M., Kistmacher V., Kretschmer A., Sebastian E., Schmitz D., Terai T., Gruendemann J., Hassan S., Patriarchi T., Reiner A., Fuhrmann M., Campbell R.E. & Masseck O.A. BioRxiv (2024): 2024.12.16.628673.

Ratiometric imaging of catecholamine neurotransmitters with nanosensors.
(former preprint: ChemRxiv (2023): 10.26434)
Ma C., Mohr J.M., Lauer G., Metternich J.T., Neutsch K., Ziebarth T., Reiner A. & Kruss S. Nano Lett. 24 (2024): 2400-2407.

2023

Axons of cortical basket cells originating from dendrites develop higher local complexity than axons emerging from basket cell somata.
Gonda S., Riedel C., Reiner A., Köhler I. & Wahle P. Development 150 (2023): dev202305.

Sensitive multicolor indicators for monitoring norepinephrine in vivo.
Kagiampaki Z., Rohner V., Kiss C., Curreli S., Dieter A., Wilhelm M., Harada M., Duss S.N., Dernic J., Bhat M.A., Zhou X., Ravotto L., Ziebarth T., Moreno Wasielewski L., Sönmez L., Benke D., Weber B., Bohacek J., Reiner A., Wiegert J.S., Fellin T. & Patriarchi T. Nat. Meth. 20 (2023): 1426-1436.

Book Chapter: Optogenetics.
Isacoff E.Y. & Reiner A.. In Encyclopedia of Cell Biology, 2nd Ed. (ed. Bradshaw R.A., Hart G.W., Stahl P.D.), Elsevier, Amsterdam. Vol. 2 (2023): 179-191.

2022

Next generation genetically encoded fluorescent sensors for serotonin.
(former preprint: BioRxiv 2022.03.10.48379937)
Kubitschke M., Müller M., Wallhorn L., Pulin M., Mittag M., Pollok S., Ziebarth T., Bremshey S., Gerdey J., Claussen K.C., Renken K., Gross J., Gneiße P., Meyer N., Wiegert J.S., Reiner A., Fuhrmann M. & Masseck O.A. Nat. Comm. 13 (2022): 7525.

2021

Structural and compositional diversity in the kainate receptor family.
Selvakumar P., Lee J., Khanra N., He C., Munguba H., Kiese L., Broichhagen J., Reiner A., Levitz J. & Meyerson J.R. Cell Rep. 37 (2021): 109891.

Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.
Herbrechter R., Hube N., Buchholz R. & Reiner A. Cell. Mol. Life Sci. 78 (2021): 5605-5630.

2020

Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization.
Pollok S. & Reiner A. Proc. Natl. Acad. Sci. USA 117 (2020): 25851-25858.

GluN2B but not GluN2A for basal dendritic growth of cortical pyramidal neurons.
Gonda S., Giesen J., Sieberath A., West F., Buchholz R., Klatt O., Ziebarth T., Räk A., Kleinhubbert S., Riedel C., Hollmann M., Hamad M.I.K., Reiner A. & Wahle P. Front. Neuroanatomy 14 (2020): 571351.

2019

Quinoxalinedione deprotonation is important for glutamate receptor binding.
Dudić A. & Reiner A. Biol. Chem. 400 (2019): 927-938.

2018

Review: Glutamatergic signaling in the central nervous system: Ionotropic and metabotropic receptors in concert.
Reiner A.# & Levitz J.#. Neuron 98 (2018): 1080-1098.

Review: New light on neurotransmitter-gated receptors: Optical approaches for controlling physiological function.
Reiner A. Neuroforum 24 (2018): A159.
in German: Neurotransmittergesteuerte Rezeptoren in neuem Licht: Optische Methoden zur Kontrolle physiologischer Funktion.
Reiner A. Neuroforum 24 (2018): 247-256.

Review: Astroglial glutamate signaling and uptake in the hippocampus.
Rose C.R., Felix L., Zeug A., Dietrich D., Reiner A. & Henneberger, C.. Front. Mol. Neurosci. 10 (2018): 00451.

2016

A family of photoswitchable NMDA receptors.
Berlin S.*/Szobota S.*, Reiner A., Carroll E.C., Kienzler M.A., Guyon A., Xiao T., Trauner D. & Isacoff, E.Y.. eLife (2016): 5:e12040.

A toolkit for orthogonal and in vivo optical manipulation of ionotropic glutamate receptors.
Levitz J.*/Popescu A.T.*/Reiner A.* & Isacoff, E.Y.. Front. Mol. Neurosci. 9 (2016): 00002.

Book Chapter: Optogenetics.
Isacoff E.Y. & Reiner A.. In Encyclopedia of Cell Biology (ed. Bradshaw R.A., Stahl P.D.), Elsevier, Amsterdam.
Encyclopedia of Cell Biology, Vol. 2 (2016): 147-155.

2015

Review: Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential.
Reiner A.*/Levitz J.* & Isacoff, E.Y.. Curr. Opin. Pharm. 20 (2015): 135-143.

2014

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.
Gaub B.M.*/ Berry M.H.*, Holt A.E., Reiner A., Kienzler M.A., Dolgova N., Nikonov S., Aguirre G.D., Beltran W.A., Flannery J. & Isacoff E.Y.. Proc. Natl. Acad. Sci. USA 111 (2014): E5574-5583.

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene.
Rullo A.*/Reiner A.*, Reiter A., Trauner D., Isacoff E.Y. & Woolley G.A.. Chem. Comm. 50 (2014): 14613-14615.

Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy.
Reiner A. & Isacoff E.Y.. Nat. Chem. Biol. 10 (2014): 273-280.

Book Chapter: Photoswitching of cell-surface receptors using tethered ligands.
Reiner A. & Isacoff E.Y.. In Photoswitching Proteins: Methods and Protocols (ed. Cambridge S.), Humana Press, New York.
Meth. Mol. Biol. 1148 (2014): 45-68.

2013

A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor.
Kienzler M.A.*/Reiner A.*, Trautman E., Yoo S., Trauner D. & Isacoff E.Y.. J. Am. Chem. Soc. 135 (2013): 17683-17686.

Optical control of metabotropic glutamate receptors.
Levitz J., Pantoja C., Gaub B., Janovjak H., Reiner A., Hoagland A., Schoppik D., Kane B., Stawski P., Schier A.F., Trauner D. & Isacoff E.Y.. Nat. Neurosci. 16 (2013): 507-516.

Testing the diffusing boundary model for the helix-coil transition in peptides.
Neumaier S., Reiner A., Büttner M., Fierz, B. & Kiefhaber T.. Proc. Natl. Acad. Sci. USA 110 (2013): 12905-12910.

Minireview: The Brain Prize 2013: The optogenetics revolution.
Reiner A. & Isacoff E.Y.. Trends Neurosci. 35 (2013): 557-560.

Perspective: Bringing optogenetics to the synapse.
Reiner A. & Isacoff E.Y.. Neuron 79 (2013): 209-210.

2012

Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex.
Reiner A., Arant R.J. & Isacoff E.Y.. Cell Rep. 1 (2012): 234-240.

2010/2011

Minireview: Triplet-triplet energy transfer studies on conformational dynamics in peptides and a protein.
Reiner A.. J. Pep. Sci. 17 (2011): 413-419.

Book Chapter: Conformational dynamics in peptides and proteins studied by triplet-triplet energy transfer.
Reiner A., Fierz B. & Kiefhaber T.. In Methods of Protein Biochemistry (ed. Tschesche H.), Walter de Gruyter, Berlin (2011): 73-94.

A reversible unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain.
Reiner A., Henklein P. & Kiefhaber T.. Proc. Natl. Acad. Sci. USA 107 (2010): 4955-4960.

2008/2009

Local conformational dynamics in α-helices measured by fast triplet transfer.
Fierz B.*/Reiner A.* & Kiefhaber T.. Proc. Natl. Acad. Sci. USA 106 (2009): 1057-1062.

NMR structure of a monomeric intermediate on the evolutionarily optimized assembly pathway of a small trimerization domain.
Habazettl J., Reiner A. & Kiefhaber T.. J. Mol. Biol. 389 (2009): 103-114.

Effect of thioxopeptide bonds on α-helix structure and stability.
Reiner A., Wildemann D., Fischer G. & Kiefhaber T.. J. Am. Chem. Soc. 130 (2008): 8079-8084.